Table 2.
Risk of Any Fracture, Likely Osteoporotic Fracture, and Hip Fracture According to Follow-Up Duodenal Histology
| Any Fracture |
Likely Osteoporotic Fracture |
Hip Fracture |
||||
|---|---|---|---|---|---|---|
| Number of Events/PYO | Adjusted HRa | Number of Events/PYO | Adjusted HRa | Number of Events/PYO | Adjusted HRa | |
| Mucosal healing | 492/34 409 | 1.0 | 124/20 617 | 1.0 | 26/37 925 | 1.0 |
| Persistent villous atrophy | 483/36 418 | 0.93 (0.82–1.06) | 96/11 916 | 1.11 (0.84–1.46) | 63/39 851 | 1.67 (1.05–2.66)b |
| Less than 1 y | ||||||
| Mucosal healing | 50/3999 | 1.0 | 11/3078 | 1.0 | 4/4284 | 1.0 |
| Persistent villous atrophy | 34/3076 | 0.95 (0.61–1.47) | 16/1561 | 2.54 (1.15–5.61)b | 3/3278 | 0.61 (0.14–2.75) |
| 1–5 y | ||||||
| Mucosal healing | 181/14 276 | 1.0 | 61/10 914 | 1.0 | 9/15 578 | 1.0 |
| Persistent villous atrophy | 106/11 484 | 0.80 (0.62–1.02) | 41/5659 | 1.06 (0.71–1.59) | 15/12 394 | 1.36 (0.59–3.12) |
| More than 5 y | ||||||
| Mucosal healing | 261/16 134 | 1.0 | 52/6625 | 1.0 | 13/18 064 | 1.0 |
| Persistent villous atrophy | 343/21 858 | 1.0 (0.85–1.18) | 39/4696 | 0.91 (0.60–1.39) | 45/24 179 | 2.18 (1.17–4.05)b |
Abbreviation: PYO, person-years of observation.
a
Adjusted for age, gender, duration of celiac disease, calendar period, and educational attainment.
b
P < .05.