Table 2.

Fasting and 2-Hour Postglucose Load BA and FGF-19 Concentrations

	BA Concentrations, μmol/L
	NGT (n = 62)	IGT (n = 25)	T2D (n = 12)	P (ANOVA)a
T-CA
Fasting	0.036 ± 0.004	0.048 ± 0.007	0.213 ± 0.147	.054
Postload	0.024 ± 0.006	0.031 ± 0.008	0.131 ± 0.076	.307
P value (fasting vs postload)	<0.001	<0.001	0.065
T-UDCA
Fasting	0.002 ± 0.001	0.006 ± 0.003	0.014 ± 0.01b	.029
Postload	0.0003 ± 0.0002	0.002 ± 0.001	0.003 ± 0.003	.122
P value (fasting vs postload)	0.004	0.018	0.537
T-MCA
Fasting	0.002 ± 0.001	0.012 ± 0.007	0.004 ± 0.003	.078
Postload	0.0007 ± 0.0005	0.005 ± 0.003b	0.003 ± 0.001	.012
P value (fasting vs postload)	0.058	0.161	0.712
T-CDCA+DCA
Fasting	0.111 ± 0.016	0.166 ± 0.043	0.441 ± 0.243b	.03
Postload	0.163 ± 0.033	0.174 ± 0.056	0.38 ± 0.176	.162
P value (fasting vs postload)	0.22	0.593	0.713
Total T-BA
Fasting	0.151 ± 0.02	0.233 ± 0.051	0.667 ± 0.391c	0.009
Postload	0.188 ± 0.039	0.212 ± 0.063	0.518 ± 0.255	0.095
P value (fasting vs postload)	0.197	0.084	0.855
G-CA
Fasting	0.168 ± 0.022	0.209 ± 0.039	0.664 ± 0.382	0.192
Postload	0.257 ± 0.047	0.233 ± 0.037	0.592 ± 0.319	0.437
P value (fasting vs postload)	0.217	0.324	0.716
G-UDCA
Fasting	0.112 ± 0.018	0.127 ± 0.04	0.15 ± 0.103	0.414
Postload	0.088 ± 0.013	0.085 ± 0.22	0.077 ± 0.043	0.288
P value (fasting vs postload)	0.345	0.033	0.293
G-CDCA+DCA
Fasting	0.995 ± 0.117	1.151 ± 0.254	1.673 ± 0.685	0.643
Postload	1.221 ± 0.163	0.932 ± 0.16	1.293 ± 0.349	0.782
P value (fasting vs postload)	0.267	0.55	0.935
Total G-BA
Fasting	1.274 ± 0.147	1.488 ± 0.311	2.487 ± 1.118	0.66
Postload	1.565 ± 0.211	1.25 ± 0.197	1.962 ± 0.659	0.745
P value (fasting vs postload)	0.325	0.581	0.82
Total conjugated
Fasting	1.425 ± 0.165	1.716 ± 0.358	3.163 ± 1.482	0.481
Postload	1.754 ± 0.243	1.463 ± 0.252	2.479 ± 0.899	0.551
P value (fasting vs postload)	0.375	0.701	0.81
CA
Fasting	0.161 ± 0.028	0.27 ± 0.115	0.099 ± 0.035	0.429
Postload	0.075 ± 0.011	0.167 ± 0.081	0.567 ± 0.022	0.293
P value (fasting vs postload)	<0.001	0.02	0.003
UDCA
Fasting	0.193 ± 0.034	0.193 ± 0.045	0.223 ± 0.113	0.848
Postload	0.15 ± 0.027	0.143 ± 0.034	0.188 ± 0.111	0.422
P value (fasting vs postload)	0.511	0.605	0.001
MCA
Fasting	0.008 ± 0.001	0.01 ± 0.002	0.009 ± 0.003	0.657
Postload	0.004 ± 0.001	0.006 ± 0.002	0.003 ± 0.001	0.676
P value (fasting vs postload)	<0.001	<0.001	0.001
CDCA+DCA
Fasting	0.913 ± 0.78	0.964 ± 0.293	0.7 ± 0.163	0.203
Postload	0.492 ± 0.038	0.57 ± 0.187	0.43 ± 0.099	0.447
P value (fasting vs postload)	<0.001	0.001	0.005
Total free BA
Fasting	1.274 ± 0.106	1.435 ± 0.397	1.014 ± 0.23	0.366
Postload	0.722 ± 0.051	0.886 ± 0.264	0.678 ± 0.167	0.567
P value (fasting vs postload)	<0.001	0.002	0.009
Total BA
Fasting	2.699 ± 0.22	3.152 ± 0.561	4.176 ± 1.54	0.848
Postload	2.475 ± 0.252	2.349 ± 0.381	3.157 ± 0.902	0.73
P value (fasting vs postload)	0.101	0.107	0.427
FGF-19 concentrations, pg/mL
FGF-19
Fasting	103 ± 10	94 ± 15	90 ± 21	0.801
Postload	146 ± 12	211 ± 39	113 ± 20	0.095
P value (fasting vs postload)	<0.001	<0.001	0.095

BA and FGF-19 concentrations of our cross-sectional study cohort (n = 99) are provided for the fasted state and 120 min after a 75-g OGTT (mean ± SE).

^aDifferences between groups at either time point were assessed by ANOVA with post hoc Tukey correction.

^bP < .05, vs NGT assessed by ANOVA.

^cP < .01, vs NGT assessed by ANOVA.