Table 3.
Clinical Characteristics of Patients with TCGA PTC with Germline RASAL1 Analysis (n = 339)
| Clinical Characteristics | All Patients (%) (n = 339) | Deleterious RASAL1 Variants (%) (n = 62) | No Deleterious RASAL1 Variants (%) (n = 277) | P Value |
|---|---|---|---|---|
| Age | ||||
| <46 y | 173 (51.0) | 35 (56.4) | 138 (49.8) | .500 |
| ≥46 y | 166 (48.9) | 27 (43.5) | 139 (50.1) | |
| Gender | ||||
| Male | 88 (26.0) | 19 (30.6) | 69 (24.9) | .569 |
| Female | 251 (74.0) | 43 (69.3) | 208 (75.1) | |
| Ethnicity | ||||
| White | 218 (62.3) | 37 (59.6) | 181 (65.3) | .471 |
| Asian | 31 (9.1) | 4 (6.5) | 27 (9.7) | |
| African American | 11 (3.2) | 1 (1.6) | 10 (3.6) | |
| Unknown | 84 (24.8) | 20 (32.2) | 64 (23.1) | |
| Histological subtype | ||||
| Follicular Variant | 78 (23.0) | 21 (33.9) | 57 (20.6) | .027 |
| Classical | 228 (67.3) | 40 (64.5) | 188 (67.9) | |
| Tall Cell Variant | 27 (8.0) | 1 (1.6) | 26 (9.4) | |
| Other | 6 (1.8) | 0 | 0 | |
| First-degree family with thyroid cancer | ||||
| Yes | 14 (4.1) | 2 (3.2) | 12 (4.3) | 1.000 |
| No | 325 (95.9) | 60 (96.8) | 265 (95.6) | |
Fisher's exact test was used to assess the significance of deleterious RASAL1 variants among patients for each clinical variable. Figures in bold indicate a P value of <.05