Table 4.
Meta-Analysis of IGF-1-Defined Outcomes as Compared Between Surgical and Medical Interventions
| Outcomes | Effect Size | 95% CI | I2, % | Heterogeneity P Value | P Value (Interaction) |
|---|---|---|---|---|---|
| Remission by cutoff criteriaa | |||||
| Medical interventions | 0.45 | (0.32, 0.63) | 86.3 | .000 | .14 |
| Surgical interventions | 0.64 | (0.54, 0.76) | 83.9 | .000 | |
| Remission by IGF-1 FUT ≤24 moa | |||||
| Medical interventions | 0.45 | (0.25, 0.81) | 84.8 | .000 | .49 |
| Surgical interventions | 0.58 | (0.38, 0.88) | 93.3 | .000 | |
| FUT ≥24 moa | |||||
| Medical interventions | 0.44 | (0.31, 0.63) | 72.5 | .026 | .24 |
| Surgical interventions | 0.56 | (0.45, 0.68) | 81.4 | .000 | |
| IGF-1 levelsb | |||||
| Medical interventions | −329.72 | (−496.73, 162.71) | 76.4 | .000 | .14 |
| Surgical interventions | −549.17 | (−791.67, −306.67) | 38.8 | .195 | |
| IGF-I levels FUT ≤24 mob | |||||
| Medical interventions | −355.34 | (−457.54, −253.15) | 0.0 | .866 | .65 |
| Surgical interventions | −412.06 | (−637.14, −186.98) | 0.0 | .661 | |
| IGF-1 levels FUT ≥24 mob | |||||
| Medical interventions | −251 | (−627.30, 125.26) | 85.9 | .001 | .04 |
| Surgical interventions | −731 | (−1007.23, −454.77) | NA | NA | |
| Tumor sizeb | |||||
| Microadenomac | −311.97 | (−571.66, −52.28) | 0.0 | .816 | .80 |
| Macroadenomac | −280.38 | (−456.44, −104.32) | 0.0 | .893 |
Abbreviations: FUT, follow-up time; NA, not applicable (not possible to calculate heterogeneity because the result was based on a single study).
a
Cumulative incidence.
b
Weighted mean difference (micrograms per liter).
c
Medical interventions only.