Table 4.
Adverse Events During Chronocort Treatment
| Adverse Event | No. Patients |
|---|---|
| Fatigue/generalized weakness | 14 |
| Headache | 14 |
| Acne | 9 |
| Dizziness | 8 |
| Weight gain | 8 |
| Infusion site pain/bruise | 7 |
| Increase in appetite | 7 |
| Acute insomnia | 6 |
| Decrease in appetite | 4 |
| Vivid dreams | 4 |
| Arthralgia (pre-existing) | 4 |
| Anemiaa | 8 |
| High blood pressure readingb | 3 |
| Acute adrenal insufficiency symptoms | 3 |
| Musculoskeletal pain | 3 |
| Nausea | 2 |
| Early awakening | 2 |
| Increased hair | 2 |
| Ear pain | 2 |
| Epistaxis | 2 |
| Palpitations | 1 |
| Acute phlebitis | 1 |
| Thinning of hair | 1 |
a
Incidental finding in three patients and possibly secondary to blood sampling in the remaining patients.
b
Two patients had high blood pressure readings at admission that resolved spontaneously. One patient had history of hypertension and was off treatment. Anti-hypertensive medication was restarted.