Table 2. Association of the RNF213 p.R4810K variant (c.14429G>A) with CAD in the primary study.
| Total (n = 1672) | Men (n = 999) | Women (n = 673) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RNF213 p.R4810K | CAD, n (%) | Control, n (%) | p value | OR (95% CI) | CAD, n (%) | Control, n (%) | p value | OR (95% CI) | CAD, n (%) | Control, n (%) | p value | OR (95% CI) | |
| Allele | G | 1873 (98.0) | 1418 (99.0) | 1359 (97.8) | 602 (99.0) | 514 (98.5) | 816 (99.0) | ||||||
| A | 39 (2.0) | 14 (1.0) | 0.017 | 2.11 (1.14–3.90) | 31 (2.2) | 6 (1.0) | 0.070 | 2.29 (0.95–5.51) | 8 (1.5) | 8 (1.0) | 0.440 | 1.59 (0.59–4.26) | |
| Additive model | GG | 919 (96.1) | 703 (98.2) | 666 (95.8) | 299 (98.4) | 253 (96.9) | 404 (98.1) | ||||||
| GA | 35 (3.7) | 12 (1.7) | 0.017 | 1.99 (1.13–3.76) | 27 (3.9) | 4 (1.3) | 0.184 | 2.04 (0.74–8.40) | 8 (3.1) | 8 (1.9) | 0.357 | 1.60 (0.58–4.39) | |
| AA | 2 (0.2) | 1 (0.1) | 3.97 (1.27–14.12) | 2 (0.3) | 1 (0.3) | 4.16 (0.55–70.61) | 0 (0) | 0 (0) | – | ||||
| Dominant model | GG | 919 (96.1) | 703 (98.2) | 666 (95.8) | 299 (98.4) | 253 (96.9) | 404 (98.1) | ||||||
| GA+AA | 37 (3.9) | 13 (1.8) | 0.019 | 2.18 (1.15–4.13) | 29 (4.2) | 5 (1.6) | 0.056 | 2.60 (1.00–6.79) | 8 (3.1) | 8 (1.9) | 0.437 | 1.60 (0.59–4.31) | |
| Recessive model | AA | 2 (0.2) | 1 (0.1) | 2 (0.3) | 1 (0.3) | 0 (0) | 0 (0) | ||||||
| GG+GA | 954 (99.8) | 715 (99.9) | 1 | 1.50 (0.14–16.56) | 693 (99.7) | 303 (99.7) | 1 | 0.87 (0.08–9.68) | 261 (100) | 412 (100) | 1 | – | |
Abbreviations: CAD, coronary artery disease; CI, confidence interval; OR, odds ratio.