Table 3. Multivariate analysis of the risk of coronary artery disease in the primary study.

Variables	Total			Men			Women
	OR	95%CI	p value	OR	95%CI	p value	OR	95%CI	p value	p for interaction with sex*
RNF213 p.R4810K (GG vs GA+AA)	2.90	1.37–6.61	0.005	4.36	1.61–14.70	0.003	1.39	0.35–5.71	0.644	0.415
Age	1.09	1.08–1.11	<0.001	1.07	1.06–1.09	<0.001	1.14	1.11–1.17	<0.001	<0.001
Sex	1.43	1.04–1.96	0.026	NA	NA	NA	NA	NA	NA	NA
Obesity	1.49	0.98–2.31	0.064	1.80	1.05–3.17	0.033	1.03	0.48–2.18	0.941	0.182
Hypertension	2.15	1.63–2.84	<0.001	2.29	1.60–3.27	<0.001	1.82	1.15–2.89	0.010	0.767
Diabetes mellitus	8.24	5.67–12.27	<0.001	7.56	4.71–12.71	<0.001	10.68	5.77–20.87	<0.001	0.619
Dyslipidemia	1.81	1.37–2.39	<0.001	1.69	1.19–2.40	0.003	1.84	1.15–2.99	0.011	0.664
Smoking	4.12	2.99–5.72	<0.001	3.08	2.18–4.37	<0.001	25.91	9.32–85.71	<0.001	<0.001

*: the p value was adjusted for age. Abbreviations: CI, confidence interval; OR, odds ratio; NA, not applicable.