Table 6. Clinical characteristics of the primary study population according to the RNF213 p.R4810K genotype (GG vs. GA+AA).
| CAD (n = 956) | Control (n = 716) | |||||
|---|---|---|---|---|---|---|
| GG | GA+AA | p value | GG | GA+AA | p value | |
| Number, n | 919 | 37 | 703 | 13 | ||
| Age, years (SD) | 71.0 (9.6) | 69.1 (11.2) | 0.249 | 58.8 (13.7) | 58.6 (14.7) | 0.961 |
| Male sex, n (%) | 666 (72.5) | 29 (78.4) | 0.418 | 299 (42.5) | 5 (38.5) | 0.768 |
| Obesity, n (%) | 127 (13.8) | 6 (16.2) | 0.686 | 55 (7.8) | 2 (15.4) | 0.370 |
| Hypertension, n (%) | 712 (77.5) | 27 (72.3) | 0.530 | 303 (43.1) | 8 (61.5) | 0.186 |
| Dyslipidemia, n (%) | 674 (73.0) | 28 (75.7) | 0.750 | 384 (54.6) | 4 (30.8) | 0.085 |
| Diabetes mellitus, n (%) | 376 (40.9) | 7 (18.9) | 0.0093 | 39 (5.6) | 0 (0) | 0.225 |
| Smoking habit, n (%) | 540 (58.8) | 22 (59.5) | 0.932 | 167 (23.8) | 3 (23.1) | 0.954 |
| BMI (kg/m2), mean (SD) | 23.5 (3.5) | 24.1 (3.6) | 0.377 | 22.9 (2.8) | 23.6 (3.5) | 0.366 |
| SBP (mmHg), mean (SD) | 132.3 (20.4) | 136.0 (20.3) | 0.273 | 126.3 (18.7) | 133.4 (20.6) | 0.177 |
| DBP (mmHg), mean (SD) | 73.0 (13.3) | 75.0 (12.9) | 0.377 | 73.4 (11.8) | 74.2 (11.4) | 0.813 |
| TG (mg/dl), mean (SD) | 136.0 (77.9) | 154.9 (96.9) | 0.153 | 101.4 (63.6) | 81.2 (40.6) | 0.255 |
| TC (mg/dl), mean (SD) | 174.4 (35.8) | 172.5 (42.9) | 0.760 | 202.6 (34.2) | 201.7 (21.8) | 0.926 |
| HDL (mg/dl), mean (SD) | 51.3 (14.8) | 55.1 (16.3) | 0.127 | 60.9 (14.9) | 64.7 (10.3) | 0.364 |
| LDL (mg/dl), mean (SD) | 98.2 (28.7) | 92.7 (30.6) | 0.256 | 121.7 (28.9) | 120.7 (19.0) | 0.901 |
| FBS (mg/dl), mean (SD) | 121.2 (44.9) | 109.0 (53.1) | 0.109 | 94.3 (14.3) | 98.5 (10.2) | 0.297 |
| Number of affected vessels | ||||||
| 1 | 365 (39.6) | 12 (34.3) | NA | NA | ||
| 2 | 262 (28.4) | 11 (31.4) | NA | NA | ||
| 3 | 294 (31.9) | 12 (34.3) | 0.852 | NA | NA | |
The differences in clinical characteristics according to the RNF213 p.R4810K genotype were evaluated in CAD patients and controls.
Data are presented as means ± SD or n (%). Continuous variables are expressed as means ± SD. Categorical variables are expressed as percentages.
Abbreviations: CAD, coronary artery disease; CI, confidence interval; DBP, diastolic blood pressure; FBS, fasting blood sugar; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride.