Fig 3. SOD1 deficiency and the HM/LF diet produce an additive increase in endothelial dysfunction and induce a non-additive decrease in vasodilator responses to nitroprusside and papaverine.
Dilatation of cerebral arterioles to acetylcholine (10−6 M [A] or 10−5 M [B]), nitroprusside (10−8 M [C] or 10−7 M [D]), and papaverine (10−6 M [E] or 10−5 M [F] was measured in Sod1+/+, Sod1+/-, and Sod1-/- mice on either control or HM/LF diet (n = 7–10 mice per group). Values are mean ± SEM. *P<0.01 compared to control diet; # P < 0.05 compared to Sod1+/+ on the same diet.