Fig 4. Partial Least Squares-Discriminant Analyses (PLS-DA) of acute over quiescent intra-subject fold changes.

Analyses were restricted to metabolites with significant mean intra-subject fold change in acute thrombotic MI that differed between groups at q<0.10. Loadings plots suggest the contributions of biochemical families of related metabolites to discriminating the study groups based on intra-subject fold change from quiescent to acute phase. (A) PLS-DA of enrollment (T0) over quiescent intra-subject fold changes. (B) PLS-DA of T6 (6 hours post enrollment) over quiescent intra-subject fold changes.