Table 1. Study phenotype criteria.

Study Phenotype	Criteria
	Troponin (ng/ml)	Histology	Presentation	Blinded Angiographic Assessment
Thrombotic MI (n = 11)	Ortho Vitros 5600 Assay: “Peak” Troponin Level >0.12 Beckman Access: “Peak” Troponin Level >0.5-and- >30% increase in troponin from T0 to T6	Histologically confirmed coronary thrombus 0–4 days old by blinded pathological assessment.	Clinical presentation consistent with WHF/ECC/ACC/AHA Universal definition of AMI	Stenosis of 50–100% in the vessel where thrombus was recovered and absence of dissection.
Non-Thrombotic MI (n = 12)	Ortho Vitros 5600 Assay: “Peak” Troponin Level >0.12 Beckman Access: “Peak” Troponin Level >0.5 -and- >30% increase in troponin from T0 to T6	No histologically confirmed thrombus recovered.	Clinical presentation consistent with WHF/ECC/ACC/AHA Universal definition of AMI	Satisfies ALL 5 criteria below, in all vessels: 1. ≤50% stenosis 2. No filling defect 3. Simple Ambrose lesion morphology 4. TIMI flow = 3 5. TIMI MPG = 3
Stable CAD (n = 15)	Ortho Vitros 5600 Assay: “Peak” Troponin Level <0.035 Beckman Access: “Peak” Troponin Level <0.04		Elective coronary angiogram History of CVD: CABG, PCI, CVA / TIA, CEA, PAD or AAA procedure–or angiographic criteria	Satisfies ALL criteria below: 1. > 50% stenosis in one or greater epicardial vessel (only required if no history of CVD) 2. TIMI flow = 3 (all vessels) 3. TIMI MPG = 3 (all vessels)

CAD = coronary artery disease, MI = myocardial infarction, TIMI = thrombolysis in myocardial infarction, MPG = myocardial perfusion grade, CABG = coronary artery bypass grafting, PCI = percutaneous coronary intervention, CVA = cerebral vascular accident, TIA = transient ischemic attack, CEA = carotid endarterectomy, PAD = peripheral artery disease, AAA = abdominal aortic aneurysm