Table 1. Clinical characteristics of IgAN patients with CKD stage 3 with different eGFR (mL/min/per 1.73m2).
| Characteristics | 55 to < 60 (n = 70) |
50 to <55 (n = 77) |
45 to < 50 (n = 63) |
40 to < 45 (n = 67) |
35 to < 40 (n = 58) |
30 to < 35 (n = 55) |
P value |
|---|---|---|---|---|---|---|---|
| Sex(male/femal) | 46/24 | 57/20 | 41/22 | 47/20 | 41/17 | 32/23 | 0.489 |
| Age (yr) | 36.94±11.67 | 41.70±11.79 | 39.52±13.05 | 40.66±12.85 | 44.93±13.50 | 36.73±12.32 | 0.003* |
| SBP (mmHg) | 129.80±18.78 | 135.61±17.41 | 135.57±16.47 | 132.94±17.29 | 136.21±16.34 | 137.38±17.94 | 0.146 |
| DBP (mmHg) | 83.39±13.89 | 87.52±11.86 | 83.40±11.55 | 85.67±14.25 | 86.76±11.99 | 88.69±10.48 | 0.086 |
| Hemoglobin (g/L) | 129.85± 19.23 | 134.04 ± 22.27 | 123.63±21.71 | 128.47±22.39 | 113.96±19.85 | 120.76±27.02 | < 0.001* |
| Serum uric acid (umol/L) | 393.43± 85.74 | 434.00± 103.68 | 407.13± 112.47 | 456.97± 133.25 | 455.12± 118.36 | 459.53± 119.01 | 0.001* |
| Scr (umol/L) | 128.19± 27.98 | 137.77± 20.76 | 146.65± 25.34 | 164.10± 31.85 | 179.19± 32.31 | 208.02± 46.29 | < 0.001* |
| Serum urea nitrogen (mmol/L) | 7.74±2.81 | 8.04± 3.18 | 8.72± 3.40 | 10.51± 3.75 | 10.40± 3.33 | 12.21± 5.00 | < 0.001* |
| eGFR(mL/min/per 1.73m2) | 57.69±1.64 | 52.64±1.35 | 47.27±1.41 | 42.48±1.42 | 37.67±1.38 | 32.34±1.39 | < 0.001* |
| Serum albumin (g/L) | 35.43±6.68 | 37.81±6.24 | 41.72±52.00 | 34.80±8.35 | 36.16±6.86 | 35.49±6.44 | 0.49 |
| Serum cholesterol (mmol/L) | 5.43±1.89 | 4.84±1.25 | 5.12±1.82 | 4.90±1.34 | 5.31±2.15 | 4.84±1.35 | 0.179 |
| Serum triglyceride(mmol/L) | 1.94±1.65 | 1.99±1.52 | 1.81±1.68 | 2.62±2.17 | 1.99±1.20 | 1.99±1.10 | 0.076 |
| Serum calcium (mmol/L) | 2.23 ± 0.13 | 2.27 ± 0.14 | 2.19±0.17 | 2.20±0.16 | 2.22±0.21 | 2.24±0.17 | 0.078 |
| Serum phosphorus (mmol/L) | 1.24 ± 0.25 | 1.22 ± 0.23 | 1.27±0.22 | 1.33±0.38 | 1.28±0.25 | 1.48±0.27 | < 0.001* |
| Proteinuria of 24-hour (g) | 1.82(3.51,6.16) | 1.60(2.60,5.34) | 2.05(4.07,7.13) | 2.08(3.52,5.26) | 2.50(4.93,5.91) | 1.96(4.29,6.26) | 0.677 |
*P<0.05.
Abbreviations: IgAN, IgA nephropathy; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; Scr, serum creatinine.