Table 6. Composite endpoints of univariate/multivariate Cox proportional hazards model analysis of IgAN patients with CKD stage 3.

	Univariate analysis		Multivariate analysis
Variables	HR (95% CI)	P value	HR (95% CI)	P value
Being in stage G3b	3.970 (2.497–6.313)	< 0.001*	2.540 (1.541–4.187)	< 0.001*
Hypertension	1.865 (1.226–2.838)	0.004*	1.839 (1.149–2.942)	0.011*
Proteinuria ≥ 3.5g/24hours	2.466 (1.621–3.751)	< 0.001*	1.844 (1.170–2.905)	0.008*
Anemia	2.162 (1.436–3.255)	< 0.001*	2.062 (1.327–3.205)	0.001*
Serum phosphorus ≥ 1.45mmol/L	3.269 (2.144–4.982)	< 0.001*	1.801 (1.144–2.836)	0.011*
Cellular crescents (%)	1.037 (1.015–1.060)	0.001*	1.041 (1.017–1.065)	0.001*
Moderate/severe interstitial lesions	4.367 (2.191–8.705)	< 0.001*	3.390 (1.597–7.194)	0.001*
Treatment with ACEI/ARB or glucocorticoids/immunosuppresants	0.491(0.281–0.855)	0.012*		0.480
Moderate/severe tubular lesions	2.112 (1.305–3.417)	0.002*		0.695
Total crescents (%)	1.017 (1.006–1.027)	0.001*		0.985
Segmental glomerulosclerosis or adhesion (%)	1.021 (1.005–1.037)	0.011*		0.311
Proliferative glomerulosclerosis (%)	1.012 (1.000–1.024)	0.047*		0.885

*P<0.05.

Variables tested in the model but not found to be significant included age and sex.

Abbreviations: IgAN, IgA nephropathy; CKD, chronic kidney disease; HR, hazard ratios.