Fig 6. Inhibition of the Akt signaling pathway sensitizes lung cancer cells to radiation.

(A-B) A549/IR cells were treated with a dual or single agent for 24 h and then treated with 6 Gy RT or directly treated with 6 Gy RT alone. Then, cell lysates were processed for the indicated proteins by western blot assay. (C-D) MTS assays showing the response of DIO and Akt inhibitors on the A549/IR cells to the radiation treatment. β-actin used as an internal normalization control. Similar results were obtained in n = 3 experiments.