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. 2017 Apr 17;12(4):e0176144. doi: 10.1371/journal.pone.0176144

Fig 3. Small intestinal immune cell responses in human microbiota associated mice suffering from acute ileitis.

Fig 3

Human microbiota associated (hma) mice were perorally infected with T. gondii strain ME49 to induce acute ileitis (ILE; grey boxes). Noninfected hma mice served as controls (N, white boxes). The average numbers of ileal (A) T lymphocytes (positive for CD3), (B) regulatory T cells (positive for FOXP3), (C) B lymphocytes (positive for B220), and (D) macrophages (positive for F4/80) from six high power fields (HPF, 400 x magnification) per animal were determined microscopically in immunohistochemically stained ileal paraffin sections at day 7 post ileitis induction. Box plots represent the 75th % and 25th % percentiles of the medians (black bar inside the boxes). Total range and significance levels (p-values) determined by the Student’s t test and Mann-Whitney U test and numbers of mice (in parentheses) are indicated. Data shown were pooled from three independent experiments.