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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Clin Cancer Res. 2016 Oct 17;23(9):2367–2373. doi: 10.1158/1078-0432.CCR-16-2154-T

Figure 2.

Figure 2

Genomic features of an exceptional responder to combined MAPK and PI3K inhibition. A, Biopsy locations from the tumor following near-total thyroidectomy (left), at recurrence (middle) and at autopsy (right). B, Phylogenetic architecture of the tumor. Putative cancer driver mutations are annotated. Red font indicated copy number gain of the indicated chromosome, blue font indicates copy number loss. Branch lengths are not proportional to number of mutations. C, Mutations detected in each biopsy.