Table 1. Patients characteristics.

Variable	Total, n=57 (%)	Patients with primary lesions, n=40 (%)	Patients with metastatic lesions, n=17 (%)	P value* (level of significance)
Age at diagnosis (years)
Median	69.0	68.1	71.0
Range	44–86	55–84	44–86
Mean	67.8	68.1	66.9	0.84
Age dichotomized (No.)
≥70 years	28 [49]	18 [45]	10 [59]
<70 years	29 [51]	22 [55]	7 [41]	0.34
Gender
Male	35 [61]	25 [62]	10 [59]
Female	22 [39]	15 [38]	7 [41]	0.79
Performance status KPS
>70%	37 [65]	22 [55]	15 [88]
≤70%	20 [35]	18 [45]	2 [12]	0.01
Pretreatment lung function
FEV1 in (% of predicted)
Available	52 [91]	39 [97]	13 [76]
Not available	5 [8]	1 [3]	4 [24]	0.01
Median	57.5	49	90
Range	18–128	18–128	40–116
Mean	62.8	54.2	88.6	0.0001
FEV1 dichotomized
≤40%	13 [25]	12 [30]	1 [7]
>40%	39 [75]	27 [70]	12 [93]	0.09
DLCO (% of predicted)
Available	32 [56]	26 [65]	6 [35]
Not available	25 [44]	14 [35]	11 [65]	0.04
Median	48	41	68
Range	14–137	14–84	57–137
Mean	47.8	40.5	79.3	0.002
DLCO dichotomized
>40%	19 [57]	13 [50]	6 [100]
≤40%	13 [43]	13 [50]	0 [0]	0.03
O2-supplementary
Yes	13 [23]	13 [32]	0 [0]
No	44 [77]	27 [68]	17 [100]	0.007
Comorbidity
CVD
Yes	25 [44]	20 [50]	5 [29]
No	32 [66]	20 [50]	12 [71]	0.15
COPD
Yes	32 [66]	30 [75]	2 [12]
No	25 [44]	10 [25]	15 [88]	0.0001
Cardiopulmonary dysfunction
Both CVD + COPD	13 [23]	12 [30]	1 [6]
One of them	31 [64]	26 [65]	5 [29]
None	13 [23]	2 [5]	11 [65]	0.0001
Pre-SABR chemotherapy
Yes	24 [42]	12 [30]	12 [70]
No	33 [68]	28 [70]	5 [30]	0.005
Post-SABR chemotherapy
Yes	21 [37]	13 [32]	8 [47]
No	36 [63]	27 [68]	9 [53]	0.29
Pre and post-SABR
Both pre and post-SABR	13 [23]	7 [16]	6 [35]
One of them	19 [33]	11 [28]	8 [47]
None	25 [44]	22 [54]	3 [18]	0.03
Previous lung surgery
Yes	14 [25]	8 [20]	6 [35]
No	43 [75]	32 [80]	11 [65]	0.22
Previous lung irradiation
Yes	5 [9]	5 [14]	0 [0]
No	52 [91]	35 [86]	17 [100]	0.12
Pre-SABR lung local treatment
Both surgery and irradiation	2 [4]	2 [6]	0 [0]
One of them	15 [26]	9 [22]	6 [35]
None	40 [70]	29 [72]	11 [65]	0.42
Post-SABR lung surgery
Yes	3 [5]	2 [5]	1 [6]
No	54 [95]	38 [95]	16 [94]	0.81
Post-SABR lung irradiation
Yes	5 [9]	2 [5]	3 [18]
No	52 [91]	38 [95]	14 [82]	0.12
Post-SABR lung local treatment
Both surgery and irradiation	1 [2]	0 [0]	1 [6]
One of them	6 [10]	4 [10]	2 [12]
None	50 [88]	36 [90]	14 [82]	0.29
No. lesion per patient	1.4	1.2	1.7	0.01
No. of treated lesions
Single lesion	40 [70]	32 [80]	8 [47]
More than one	17 [30]	8 [20]	9 [53]	0.01

*, pearson chi-square test for categorical and Mann-Whitney U test for continuous variables. KPS, Karnofsky performance status; FEV₁, forced expiratory volume during the first second; DLCO, diffusing capacity of the lung for carbon monoxide; CVD, cardiovascular disease; COPD, chronic obstructive pulmonary disease; SABR, stereotactic ablative radiotherapy.