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. 2017 Mar;9(3):742–756. doi: 10.21037/jtd.2017.03.07

Table 3. Treatment characteristics.

Variable Total, n=77 (%) PLLs, n=49 (%) MLLs, n=28 (%) P value* (level of significance)
Interval between the first diagnosis and the start of SABR (in days)
   Median 48.0 48.0 52.0
   Range 14–170 14–170 20–141
   Mean 57.2 57.9 56.0 0.79
Interval dichotomized
   ≤48 days 39 [51] 26 [54] 13 [47]
   >48 days 38 [49] 23 [46] 15 [53] 0.57
SABR duration (in days)
   Median 9.0 9.0 7.0
   Range 5–23 5–23 5–19
   Mean 9.6 10.0 8.9 0.12
SABR duration dichotomized
   <9 days 37 [48] 23 [46] 14 [50]
   ≥9 days 40 [52] 26 [54] 14 [50] 0.79
No. of fractions
   Median 5.0 5.0 5.0
   Range 3–10 3–10 3–8
   Mean 5 5.4 4.3 0.03
No. of fractions dichotomized
   <5 fractions 35 [45] 22 [45] 13 [47]
   ≥5 fractions 42 [55] 27 [55] 15 [53] 0.89
Dose per fraction in Gy
   Median 12 12 12
   Range 3.6–18 3.6–18 5–12.5
   Mean 10.2 10.4 9.9 0.86
Dose per fraction dichotomized
   ≥12 Gy 46 [60] 30 [61] 16 [57]
   <12 Gy 31 [40] 19 [39] 12 [43] 0.72
Total dose in Gy
   Median 48 48 36
   Range 25–60 30–60 25–60
   Mean 47.9 52 40.5 0.001
Total dose dichotomized
   ≤48 Gy 49 [64] 26 [53] 23 [82]
   >48 Gy 28 [36] 23 [47] 5 [18] 0.01
Prescription isodose line
   80–95% 60 [78] 48 [98] 12 [43]
   60–65% 17 [22] 1 [2] 16 [57] 0.0001
BED10 (peripheral)
   Median 105 105 79
   Range 37–151 48–151 37–132
   Mean 97.2 105.8 82 0.0001
BED10 dichotomized
   ≥105 Gy 48 [62] 41 [84] 7 [25]
   <105 Gy 29 [38] 8 [16] 21 [75] 0.0001
Treatment planning technique
   3D conformal 50 [65] 33 [67] 17 [60]
   IMRT 27 [35] 16 [33] 11 [40] 0.56
PTV volume in mL
   Median 27 29 20
   Range 4–147 5–147 4–98
   Mean 33.8 37 28 0.12

*, pearson chi-square test for categorical and Mann-Whitney U test for continuous variables. PLLs, primary lung lesions; MLLs, metastatic lung lesions; SABR, stereotactic ablative radiotherapy; BED10, biologic effective dose at α/β=10 Gy; 3D, three dimensional; IMRT, intensity-modulated radiation therapy; PTV, planning target volume.