Table 3. Treatment characteristics.
Variable | Total, n=77 (%) | PLLs, n=49 (%) | MLLs, n=28 (%) | P value* (level of significance) |
---|---|---|---|---|
Interval between the first diagnosis and the start of SABR (in days) | ||||
Median | 48.0 | 48.0 | 52.0 | |
Range | 14–170 | 14–170 | 20–141 | |
Mean | 57.2 | 57.9 | 56.0 | 0.79 |
Interval dichotomized | ||||
≤48 days | 39 [51] | 26 [54] | 13 [47] | |
>48 days | 38 [49] | 23 [46] | 15 [53] | 0.57 |
SABR duration (in days) | ||||
Median | 9.0 | 9.0 | 7.0 | |
Range | 5–23 | 5–23 | 5–19 | |
Mean | 9.6 | 10.0 | 8.9 | 0.12 |
SABR duration dichotomized | ||||
<9 days | 37 [48] | 23 [46] | 14 [50] | |
≥9 days | 40 [52] | 26 [54] | 14 [50] | 0.79 |
No. of fractions | ||||
Median | 5.0 | 5.0 | 5.0 | |
Range | 3–10 | 3–10 | 3–8 | |
Mean | 5 | 5.4 | 4.3 | 0.03 |
No. of fractions dichotomized | ||||
<5 fractions | 35 [45] | 22 [45] | 13 [47] | |
≥5 fractions | 42 [55] | 27 [55] | 15 [53] | 0.89 |
Dose per fraction in Gy | ||||
Median | 12 | 12 | 12 | |
Range | 3.6–18 | 3.6–18 | 5–12.5 | |
Mean | 10.2 | 10.4 | 9.9 | 0.86 |
Dose per fraction dichotomized | ||||
≥12 Gy | 46 [60] | 30 [61] | 16 [57] | |
<12 Gy | 31 [40] | 19 [39] | 12 [43] | 0.72 |
Total dose in Gy | ||||
Median | 48 | 48 | 36 | |
Range | 25–60 | 30–60 | 25–60 | |
Mean | 47.9 | 52 | 40.5 | 0.001 |
Total dose dichotomized | ||||
≤48 Gy | 49 [64] | 26 [53] | 23 [82] | |
>48 Gy | 28 [36] | 23 [47] | 5 [18] | 0.01 |
Prescription isodose line | ||||
80–95% | 60 [78] | 48 [98] | 12 [43] | |
60–65% | 17 [22] | 1 [2] | 16 [57] | 0.0001 |
BED10 (peripheral) | ||||
Median | 105 | 105 | 79 | |
Range | 37–151 | 48–151 | 37–132 | |
Mean | 97.2 | 105.8 | 82 | 0.0001 |
BED10 dichotomized | ||||
≥105 Gy | 48 [62] | 41 [84] | 7 [25] | |
<105 Gy | 29 [38] | 8 [16] | 21 [75] | 0.0001 |
Treatment planning technique | ||||
3D conformal | 50 [65] | 33 [67] | 17 [60] | |
IMRT | 27 [35] | 16 [33] | 11 [40] | 0.56 |
PTV volume in mL | ||||
Median | 27 | 29 | 20 | |
Range | 4–147 | 5–147 | 4–98 | |
Mean | 33.8 | 37 | 28 | 0.12 |
*, pearson chi-square test for categorical and Mann-Whitney U test for continuous variables. PLLs, primary lung lesions; MLLs, metastatic lung lesions; SABR, stereotactic ablative radiotherapy; BED10, biologic effective dose at α/β=10 Gy; 3D, three dimensional; IMRT, intensity-modulated radiation therapy; PTV, planning target volume.