Table 3. Time-dependent changes in serum BNP, CK-MB, troponin, creatinine and urine volume.
| Parameters | Time sector | P-valuea within groups | P-valueb between groups | |||
|---|---|---|---|---|---|---|
| Immediate after surgery | 1st day after surgery | 2nd day after surgery | 3rd day after surgery | |||
| Troponin (ng/mL) | <0.0001 | <0.0001 | ||||
| Con (n=147) | 1.47±0.42 | 9.40±1.20 | 6.14±0.54 | 4.40±0.36 | ||
| rhBNP (n=210) | 1.48±0.40 | 9.26±1.20 | 5.54±0.65 | 3.81±0.72 | ||
| P-valuec | 0.86 | 0.31 | <0.0001 | <0.0001 | ||
| BNP (pg/mL) | <0.0001 | 0.02 | ||||
| Con (n=147) | 1,498.84±226.65 | 1,390.27±264.27 | 654.38±137.21 | 389.65±73.69 | ||
| rhBNP (n=210) | 1,520.23±246.93 | 1,388.79±325.80 | 549.51±97.50 | 376.54±65.90 | ||
| P-valuec | 0.40 | 0.96 | <0.0001 | 0.09 | ||
| Serum creatinine (ìmol/L) | <0.0001 | <0.0001 | ||||
| Con (n=147) | 87.13±19.83 | 87.89±17.79 | 116.33±6.62 | 143.71±16.14 | ||
| rhBNP (n=210) | 85.01±20.05 | 83.70±18.98 | 95.12±19.79 | 122.30±15.17 | ||
| P-valuec | 0.32 | 0.03 | <0.0001 | <0.0001 | ||
| CK-MB | <0.0001 | 0.23 | ||||
| Con (n=147) | 5.34±0.73 | 7.20±0.85 | 5.24±0.69 | 2.74±0.98 | ||
| rhBNP (n=210) | 5.25±0.71 | 7.15±0.81 | 5.08±0.88 | 2.82±1.10 | ||
| P-valuec | 0.24 | 0.62 | 0.06 | 0.48 | ||
| Urine volume (mL) | <0.0001 | <0.0001 | ||||
| Con (n=147) | NA | 2,312.97±409.55 | 2,203.27±402.39 | 2,206.94±418.33 | ||
| rhBNP (n=210) | NA | 2,355.13±442.18 | 2,751.49±444.00 | 2,806.30±427.99 | ||
| P-valuec | NA | 0.36 | <0.0001 | <0.0001 | ||
Data are presented as the mean value ± SEM. a, Differences within control group or rhBNP group of time-dependent change after CPB surgery (using the general lineal model for repeated measures analysis); b, differences between control group and rhBNP group of time-dependent change after CPB surgery (using the general lineal model for repeated measures analysis); c, differences of mean values between control group and rhBNP group in each time sector (as determined using Student t-test).