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. 2017 Mar;9(3):779–788. doi: 10.21037/jtd.2017.03.21

Table 4. A summary of previous studies that assessed pulmonary hypertension (PH) in patients with obesity hypoventilation syndrome.

Study Study design Sample characteristics PAP assessment method Definition of PH Prevalence of PH
Kessler et al. (9) Prospectively collected clinical data n=27; age =61 yr; BMI =40 kg/m2 Right-heart catheterization Mean PAP >20 mmHg 59%
Kauppert et al. (23) Prospective cross-sectional study of patients who were on NIV therapy n=21; BMI =45 kg/m2; prior to enrollment, patients were treated with NIV for a mean of 1.9 yr. PCO2 and PO2 data prior to NIV were not reported Right-heart catheterization Mean PAP >20 mmHg 81% had mild to moderate PH
Alawami et al. (10) A retrospective analysis of dataset n=25 Transthoracic echocardiography Systolic PAP >30 mmHg 88%
Sugerman et al. (24) Prospective study n=26; age =44 yr; BMI not reported; did not use the standard diagnostic criteria for OHS; pre-operative assessment for Bariatric surgery Right-heart catheterization Mean PAP ≥20 mmHg 88%
Held et al. (8) Retrospective study n=12 (3 of them had co-existing COPD); age =62 yr; BMI =36 kg/m2 Right-heart catheterization and transthoracic echocardiography Mean PAP at rest ≥25 mmHg or mean PAP at rest <25 mmHg and mean PAP at exercise ≥50 mmHg or, an echocardiographic systolic PAP ≥50 mmHg at rest Not reported (mean PAP =49±13 mmHg)
Marik & Desai (25) Retrospective study n=61 (77% women and 92% black); age =59 yr; BMI =48.9 kg/m2 Transthoracic echocardiography; the peak tricuspid regurgitant velocity was used; to estimate the systolic PAP Systolic PAP >35 mmHg; systolic PAP >45 mmHg (moderate to severe PH) 77%; 41% (moderate to severe PH)
Current study Prospective observational cross-sectional study n=77; age =60.5 yr; no prior treatment with NIV Transthoracic echocardiography Systolic PAP >40 mmHg 68.8%