Table S1. The expressed profile of cytokines involved in the pathogenesis of patients with IPF and INSIP.
| Symbol | Description | GO term | 1A: standard value/control standard value | 4A: standard value/control standard value | 6A: standard value/control standard value | 5A: standard value/control standard value | 8A: standard value/control standard value | 10A: standard value/control standard value |
|---|---|---|---|---|---|---|---|---|
| RPS27A | Ribosomal protein S27a | Intracellular; protein biosynthesis; structural constituent of ribosome; ribosome | 0.6984812 | 0.88565386 | 1.15274426 | 0.71415456 | 1.21272104 | 1.169643001 |
| AREG | Amphiregulin (schwannoma-derived growth factor) | Integral to membrane; cell proliferation; extracellular space; growth factor activity; cell-cell signaling; cytokine activity | 0.36046713 | 0.54934792 | 1.94266824 | 0.13030534 | 0.60418898 | 1.82350768 |
| ARS | ARS component B | Extracellular; cytokine activity; biological process unknown | 1.08435248 | 1.51541266 | 0.88175234 | 0 | 0.62953952 | 0.915287115 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | ATP binding; hydrolase activity; transporter activity; hydrogen-transporting ATP synthase activity, rotational mechanism; hydrogen-transporting ATPase activity, rotational mechanism; ATP synthesis coupled proton transport; proton-transporting two-sector ATPase complex; proton transport | 0.57892632 | 0.81518827 | 1.20603347 | 0.21065414 | 1.18184632 | 0.870057203 |
| BMP1 | Bone morphogene tic protein 1 | Calcium ion binding; extracellular; proteolysis and peptidolysis; zinc ion binding; development; growth factor activity; cytokine activity; metallopeptidase activity; cartilage condensation; astacin activity; procollagen C-endopeptidase activity | 0.44907116 | 1.53291465 | 2.36971787 | 1.49313203 | 1.77526707 | 1.941768055 |
| BMP10 | Bone morphogene tic protein 10 | Extracellular; cell growth and/or maintenance; growth factor activity; cell-cell signaling; regulation of cell proliferation; cytokine activity; embryonic development; growth; cardioblast differentiation; embryonic heart tube development | 0.88372109 | 1.25930558 | 0.8686157 | 1.55617516 | 0 | 1.551193053 |
| BMP15 | Bone morphogene tic protein 15 | Extracellular; cell growth and/or maintenance; growth factor activity; cytokine activity; female gamete generation | 1.63601749 | 1.70915606 | 1.30182138 | 1.87381476 | 0.65265595 | 2.545671034 |
| BMP2 | Bone morphogene tic protein 2 | Extracellular; cell growth and/or maintenance; growth factor activity; skeletal development; cell-cell signaling; cytokine activity; growth | 0.41148814 | 0.53024484 | 1.28156685 | 0.67825423 | 0.89965975 | 1.225958449 |
| BMP3 | Bone morphogene tic protein 3 (osteogenic) | Growth factor activity; skeletal development; cell-cell signaling; cytokine activity | 0.4218214 | 0.80764214 | 0.67738821 | 0.58399011 | 0.8947683 | 0.926961445 |
| BMP4 | Bone morphogene tic protein 4 | Mesoderm development; signal transducer activity; growth factor activity; skeletal development; cytokine activity; growth | 0.68117675 | 0.94967571 | 1.35208101 | 0.40737043 | 0.37587385 | 1.032840747 |
| BMP5 | Bone morphogene tic protein 5 | Cellular component unknown; growth factor activity; skeletal development; cytokine activity; growth | 0.80459129 | 0.88061403 | 0.84268902 | 0.63724704 | 3.87536045 | 1.74188967 |
| BMP6 | Bone morphogene tic protein 6 | Growth factor activity; skeletal development; cytokine activity; growth | 0.4338411 | 0.45341569 | 1.28857593 | 0.4882698 | 1.85010961 | 1.305614283 |
| BMP7 | Bone morphogene tic protein 7 (osteogenic protein 1) | Growth factor activity; skeletal development; cytokine activity; growth | 0.60980249 | 1.16194954 | 1.70558442 | 2.43253239 | 1.17500204 | 3.415602872 |
| BMP8B | Bone morphogene tic protein 8b (osteogenic protein 2) | Extracellular; cell growth and/or maintenance; growth factor activity; skeletal development; cytokine activity; growth | 0.44606252 | 1.00370687 | 1.26870185 | 1.57379029 | 0.63197258 | 2.800244206 |
| CSF1 | Colony stimulating factor 1 (macrophage) | Integral to membrane; cell proliferation; positive regulation of cell proliferation; cell differentiation; hematopoiesis; macrophage differentiation; macrophage colony stimulating factor receptor binding | 0.39762743 | 0.85268102 | 1.69268968 | 1.62542045 | 0.62966387 | 7.966210029 |
| CSF2 | Colony stimulating factor 2 (granulocyte-macrophage) | Cell surface receptor linked signal transduction; development; extracellular space; cytokine activity; cellular defense response; granulocyte macrophage colony-stimulating factor receptor binding | 0.86439825 | 2.1039088 | 1.56077784 | 2.30494703 | 3.91822998 | 4.675454723 |
| CSF3 | Colony stimulating factor 3 (granulocyte) | Extracellular; immune response; positive regulation of cell proliferation; cell surface receptor linked signal transduction; development; extracellular space; cell-cell signaling; cytokine activity; interleukin-6 receptor binding; cellular defense response; granulocyte colony-stimulating factor receptor binding | 0.1869539 | 0.40499611 | 0.40866589 | 0.43818644 | 0.56068614 | 0.823405602 |
| CYFIP2 | Cytoplasmic FMR1 interacting protein 2 | Extracellular; immune response; chemokine activity | 0.21420331 | 0.25539393 | 1.30377059 | 0.44353184 | 1.90888968 | 0.527755359 |
| EBAF | Endometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily) | Growth factor activity; cell-cell signaling; cytokine activity; transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor binding; cell growth; oocyte axis determination | 1.21764497 | 0 | 1.15646718 | 2.06761498 | 0.81054292 | 0.924354838 |
| FAM3B | Family with sequence similarity 3, member B | Extracellular; cytokine activity; insulin secretion | 0.78531381 | 0.65905041 | 2.229818 | 1.28087945 | 4.95090772 | 4.701887783 |
| FAM3C | Family with sequence similarity 3, member C | Extracellular; cytokine activity; biological process unknown | 0.49964231 | 0.89692954 | 3.18000379 | 1.77520073 | 6.25169364 | 3.125564115 |
| FGF10 | Fibroblast growth factor 10 | Signal transduction; nucleus; regulation of cell cycle; extracellular space; heparin binding; organogenesis; growth factor activity; cell-cell signaling; response to stress; regulation oftranscription; fibroblast growth factor receptor signaling pathway; cell surface; protein-nucleus import, translocation; fibro blast growth factor receptor binding; embryonic limb morphogenesis; positive regulation of receptor mediated endocytosis; positive regulation of urothelial cell proliferation; urothelial cellproliferation | 3.19600254 | 4.89922147 | 5.88637612 | 2.51792617 | 4.16436653 | 2.088285455 |
| FIGF | C-fos induced growth factor (vascular endothelial growth factor D) | Cell proliferation; regulation of cell cycle; positive regulation of cell proliferation; membrane; extracellular space; growth factor activity; platelet-derived growth factor receptor binding; angiogenesis | 0.34008861 | 0.73039865 | 0.6914384 | 1.90344681 | 0.57572558 | 3.60552752 |
| FLT3LG | Fms-related tyrosine kinase 3 ligand | Integral to membrane; signal transduction; positive regulation of cell proliferation; soluble fraction; cytokine activity | 0.14434829 | 0.93506638 | 1.40548726 | 1.0582324 | 1.66671187 | 1.121110141 |
| GDF1 | Growth differentiation factor 1 | Extracellular; cell growth and/or maintenance; growth factor activity; cell differentiation; cytokine activity | 0.71304012 | 1.20313207 | 0.13961967 | 1.73922252 | 0.58195599 | 0.568924283 |
| GDF10 | Growth differentiation factor 10 | Growth factor activity; skeletal development; cytokine activity; transforming growth factor beta receptor signaling pathway | 0.19112295 | 0.4487812 | 0.51587711 | 0.59738119 | 1.10692823 | 1.029270193 |
| GDF11 | Growth differentiation factor 11 | Cellular component unknown; mesoderm development; growth factor activity; skeletal development; neurogenesis; cytokine activity; growth | 0.49771627 | 0.92771365 | 1.70170279 | 1.02288945 | 0.75853251 | 0.946061695 |
| GDF15 | Growth differentiation factor 15 | Signal transduction; extracellular; growth factor activity; cell-cell signaling; cytokine activity; transforming growth factor beta receptor signaling pathway | 1.16324212 | 1.25200137 | 2.17175906 | 1.03014713 | 2.08572453 | 1.630074383 |
| GDF2 | Growth differentiation factor 2 | Extracellular; cell growth and/or maintenance; growth factor activity; cytokine activity; growth | 0.67075334 | 1.78379253 | 1.15515494 | 1.24631474 | 0.9995993 | 1.320697065 |
| GDF3 | Growth differentiation factor 3 | Extracellular; cell growth and/or maintenance; growth factor activity; cytokine activity | 0.42614976 | 1.46617164 | 5.84659285 | 1.18540565 | 2.58311126 | 12.87213207 |
| GDF5 | Growth differentiation factor 5 (cartilage-derived morphogene tic protein-1) | Protein binding; growth factor activity; cell-cell signaling; cytokine activity; transforming growth factor beta receptor signaling pathway; growth | 0.09844814 | 0.76816607 | 1.50746376 | 1.1620905 | 3.08452196 | 3.312303835 |
| GDF8 | Growth differentiation factor 8 | Growth factor activity; muscle development; cytokine activity; transforming growth factor beta receptor signaling pathway; growth | 0 | 0 | 0 | 0 | 0 | 0 |
| GDF9 | Growth differentiation factor 9 | Extracellular; cell growth and/or maintenance; growth factor activity; cytokine activity; transforming growth factor beta receptor signaling pathway; female gamete generation | 1.5551875 | 1.88818857 | 0 | 1.51274806 | 0.93594492 | 0.554337305 |
| IFNA1 | Interferon, alpha 1 | – | 1.54500454 | 1.16844903 | 0.59446116 | 1.71518551 | 1.27340387 | 0.919061148 |
| IFNA13 | Interferon, alpha 13 | Extracellular; defense response; interferon-alpha/beta receptor binding | 1.82956475 | 1.08339289 | 1.27299482 | 1.85809945 | 0.72289898 | 1.125587879 |
| IFNA14 | Interferon, alpha 14 | Extracellular; defense response; hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 1.18464548 | 0.91799836 | 1.20976248 | 1.22168442 | 1.50826849 | 1.573881337 |
| IFNA2 | Interferon, alpha 2 | Extracellular; induct ion of apoptosis; inflammatory response; cell surface receptor linked signal transduction; cell-cell signaling; defense response; interferon-alpha/beta receptor binding | 1.88261574 | 1.7431851 | 1.38292725 | 1.92205808 | 0.96346873 | 1.423555669 |
| IFNA4 | Interferon, alpha 4 | Extracellular; response to virus; cell-cell signaling; defense response; interferon-alpha/beta receptor binding | 1.17361593 | 1.06252523 | 1.92194785 | 2.76220278 | 1.33646694 | 2.699104604 |
| IFNA5 | Interferon, alpha 5 | Extracellular; defense response; hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 1.23818065 | 1.65148932 | 1.27750868 | 14.6657583 | 6.37817411 | 33.94323995 |
| IFNA8 | Interferon, alpha 8 | Extracellular; defense response; hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 0.114951 | 0.58061597 | 0.74191419 | 0.50904098 | 0.76927753 | 0.482888981 |
| IFNB1 | Interferon, beta 1, fibroblast | Extracellular; negative regulation of cell proliferation; cell surface receptor linked signal transduction; response to virus; Caspase activation; B-cell proliferation; defense response; natural killer cell activation; positive regulation of innate immune response; interferon-alpha/beta receptor binding; anti-inflammatory response; negative regulation of virion penetration; regulation of MHC class I biosynthesis | 1.77661581 | 0.70740493 | 1.18248114 | 1.72889506 | 1.12276541 | 0.984607959 |
| IFNG | Interferon, gamma | Regulation of cell growth; extracellular; immune response; cell surface receptor linked signal transduction; cell motility; cell-cell signaling; cytokine activity; interferon-gamma receptor binding | 1.7167365 | 0.67814498 | 1.88857383 | 1.93853225 | 7.61475888 | 0.973028806 |
| IFNK | Interferon, kappa | Extracellular; negative regulation of cell proliferation; response to virus; defense response; regulation of transcription; cytokine and chemokine mediated signaling pathway; natural killer cell activation; cellular defense response (sensu vertebrata); positive regulation of innate immune response; Interferon-alpha/beta receptor binding | 1.31719373 | 1.01248042 | 0.53252278 | 0.92103371 | 0.58158402 | 1.143468571 |
| IFNW1 | Interferon, omega 1 | Extracellular; response to virus; cell cycle arrest; defense response; interferon-alpha/beta receptor binding | 1.42434696 | 1.21945239 | 1.18832803 | 1.71327051 | 0.58954076 | 1.049929566 |
| IK | IK cytokine, down-regulator of HLA II | Immune response; extracellular space; soluble fraction; cell-cell signaling; cytokine activity | 1.64646668 | 1.8741568 | 1.06467638 | 1.10080838 | 0.38592034 | 0.599044565 |
| IL10 | Interleukin 10 | Extracellular; Immune response; anti-apoptosis; cell-cell signaling; B-cell proliferation; cytokine activity; B-cell differentiation; T-helper 2 type immune response; regulation of isotype switching; interleukin-10 receptor binding; cytoplasmic sequestering of NF-kappaB; hematopoiesis; immune cell chemotaxis; negative regulation of MHC class ii biosynthesis; negative regulation of t-cell proliferation; negative regulation of interferon-alpha biosynthesis; negative regulation of interferon-gamma biosynthesis; negative regulation of nitric oxide biosynthesis | 0.63884315 | 1.6675018 | 0.53983092 | 0.63422976 | 0.95138832 | 0.453962045 |
| IL11 | Interleukin 11 | Extracellular; positive regulation of cell proliferation; cell-cell signaling; plateletactivation; cytokine activity; B-cell differentiation; interleukin-11 receptor binding; adipocyte differentiation; megakaryocyte differentiation | 1.96323506 | 1.85343374 | 0.73993446 | 6.74102002 | 3.14383543 | 7.594803581 |
| IL12A | Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | – | 1.24653313 | 1.34306261 | 1.84622945 | 2.99207674 | 2.21844084 | 5.456309813 |
| IL12B | Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | Signal transducer activity; membrane; extracellular space; antimicrobial humoral response (sensu vertebrata); positive regulation of interferon-gamma biosynthesis; cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-12 receptor binding; T-helper cell differentiation; interferon-gamma biosynthesis; natural killer cell activation; positive regulation of activated T-cell proliferation; regulation of cytokine biosynthesis | 1.70500651 | 1.06834274 | 0.95909508 | 3.1452199 | 0.82850509 | 0.876244301 |
| IL13 | Interleukin 13 | Cell proliferation; signal transduction; extracellular; immune response; inflammatory response; signal transducer activity; soluble fraction; cell motility; antimicrobial humoral response (sensu vertebrata); cell-cell signaling; chemokine activity; interleukin-13 receptor binding | 1.21004911 | 1.62433632 | 0.72171694 | 0.75596692 | 0.66550881 | 0.642189933 |
| IL14 | Taxilin | Cell proliferation; extracellular; high molecular weight B-cell growth factor receptor binding | 0.52526398 | 0.88536095 | 1.06673542 | 0.71710052 | 1.42119473 | 0.658870839 |
| IL15 | Interleukin 15 | Golgi apparatus; cell proliferation; signal transduction; immune response; positive regulation of cell proliferation; membrane fraction; signal transducer activity; integral to plasmamembrane; extracellular space; endosome; cell-cell signaling; hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 0.70213539 | 0.82335532 | 1.10137384 | 0.6390786 | 1.47449891 | 0.625214574 |
| IL16 | Interleukin 16 (lymphocyte chemoattractant factor) | Immune response; protein binding; extracellular space; chemotaxis; cytokine activity | 1.58139564 | 1.24719248 | 1.82767665 | 1.73220471 | 1.88149791 | 0.803103305 |
| IL17 | Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) | Immune response; apoptosis; extracellular space; cell death; cell-cell signaling; cytokine activity; protein amino acid glycosylation | 9.80067608 | 7.4405083 | 1.39902053 | 5.41101957 | 1.64419825 | 3.46121765 |
| IL17B | Interleukin 17B | Immune response; signal transducer activity; cell-cell signaling; cytokine activity | 1.15724256 | 1.33395919 | 1.42822417 | 2.55111625 | 1.08124331 | 3.214249272 |
| IL17C | Interleukin 17C | Inflammatory response; cell surface receptor linked signal transduction; extracellular space; soluble fraction; cell-cell signaling; cytokine activity | 1.73479304 | 3.92625774 | 1.46620866 | 1.39194436 | 0.58171142 | 1.654175954 |
| IL17E | Interleukin 17E | Membrane; cytokine activity; interleukin-17E receptor binding; biological process unknown | 0.82060846 | 0.76920313 | 1.22449616 | 1.68156722 | 0.20627228 | 0 |
| IL17F | Interleukin 17F | Extracellular; cytokine activity; negative regulation of angiogenesis; cytokine biosynthesis; proteoglycan metabolism | 1.76371006 | 1.32606734 | 1.93859107 | 1.24426497 | 1.16497143 | 0.810622138 |
| IL18 | Interleukin 18 (interferon-gamma-inducing factor) | Extracellular; immune response; induction of apoptosis via death domain receptors; signal transducer activity; interleukin-1 receptor binding; cell-cell signaling; angiogenesis; interferon-gamma biosynthesis; positive regulation of activated T-cell proliferation; T-helper 2 type immune response; chemokine biosynthesis; granulocyte macrophage colony-stimulating factor biosynthesis; Interleukin-13 biosynthesis; Interleukin-2 biosynthesis; regulation of cell adhesion; sleep | 1.04899764 | 1.11062992 | 0.95779984 | 0.8448451 | 0.77969744 | 0.662700197 |
| IL19 | Interleukin 19 | Signal transduction; extracellular; immune response; cytokine activity; actin binding | 3.01819304 | 1.93573526 | 1.63277351 | 1.63144336 | 0.87518143 | 1.82184604 |
| IL1A | Interleukin 1, alpha | Cell proliferation; immune response; cytoplasm; apoptosis; anti-apoptosis; negative regulation of cell proliferation; regulation of cell cycle; inflammatory response; signal transducer activity; extracellular space; interleukin-1 receptor binding; cell-cell signaling; chemotaxis | 0.92241657 | 2.3689492 | 1.7958075 | 1.79342661 | 1.68340863 | 1.482172667 |
| IL1B | Interleukin 1, beta | Cell proliferation; signal transduction; immune response; apoptosis; negative regulation of cell proliferation; regulation of cell cycle; inflammatory response; signal transducer activity; extracellular space; interleukin-1 receptor binding; antimicrobial humoral response (sensu vertebrata); cell-cell signaling | 1.69998232 | 1.59534836 | 2.28855983 | 1.25859418 | 11.2163116 | 1.721077691 |
| IL1F10 | Interleukin 1 family, member 10 (theta) | Extracellular; immune response; interleukin-1 receptor antagonist activity | 1.64501992 | 6.15108437 | 1.53726768 | 4.18960317 | 1.67940221 | 1.643218455 |
| IL1F5 | Interleukin 1 family, member 5 (delta) | Extracellular; immune response; interleukin-1 receptor antagonist activity | 1.49668861 | 7.90464734 | 1.45959404 | 3.85410687 | 1.31685159 | 4.478736387 |
| IL1F6 | Interleukin 1 family, member 6 | Extracellular; immune response; inflammatory response; interleukin-1 receptor binding | 1.35784015 | 1.39803102 | 0.70685224 | 1.81789403 | 0.22921418 | 0.926796096 |
| IL1F7 | Interleukin 1 family, member 7 (zeta) | Extracellular; immune response; interleukin-1 receptor antagonist activity | 1.52926815 | 1.70695734 | 1.27934853 | 1.20834604 | 0.31098844 | 1.094279548 |
| IL1F8 | Interleukin 1 family, member 8 (eta) | Extracellular; immune response; interleukin-1 receptor binding | 7.63819507 | 3.66816028 | 1.75098682 | 2.81217976 | 0.68113273 | 4.543417181 |
| IL1F9 | Interleukin 1 family, member 9 | Extracellular; immune response; cell-cell signaling; interleukin-1 receptor antagonist activity; response to pest, pathogen or parasite | 10.6074733 | 0.91372598 | 2.00002979 | 4.22983771 | 1.52435628 | 1.226817076 |
| IL2 | Interleukin 2 | – | 7.68503718 | 0.77761967 | 1.10690276 | 1.77467021 | 0.83628448 | 1.282571949 |
| IL20 | Interleukin 20 | Extracellular; immune response; interleukin-20 receptor binding; positive regulation of epidermal cell differentiation; positive regulation of keratinocyte differentiation; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of inflammatory response | 8.13303416 | 0.60438263 | 0.66200638 | 2.12157085 | 1.04528241 | 1.454492023 |
| IL21 | Interleukin 21 | Signal transduction; Nucleus; cytokine activity; lymph gland development | 3.93130568 | 1.93819257 | 0.50450821 | 1.88498697 | 0.28569141 | 1.256471497 |
| IL22 | Interleukin 22 | Extracellular; inflammatory response; acute-phase response; cell-cell signaling; interleukin-22 receptor binding | 2.24882983 | 1.00427292 | 0.82387008 | 2.06062241 | 0.70705756 | 1.627601657 |
| IL24 | Interleukin 24 | Extracellular; immune response; apoptosis; cytokine activity | 0.91127363 | 0.8669872 | 0.94603635 | 1.89331206 | 0.60682735 | 1.33606596 |
| IL26 | Interleukin 26 | Immune response; extracellular space; soluble fraction; antimicrobial humoral response (sensu vertebrata); cell-cell signaling; cytokine activity | 1.59430708 | 1.88389603 | 0.75213864 | 1.71489213 | 0.50874937 | 0.402468096 |
| IL3 | Interleukin 3 (colony-stimulating factor, multiple) | Cell proliferation; extracellular; immune response; positive regulation of cell proliferation; cell-cell signaling; neurogenesis; cytokine activity; interleukin-3 receptor binding | 1.31838154 | 1.96864535 | 1.67101865 | 1.69908821 | 0.59010334 | 2.797392551 |
| IL4 | Interleukin 4 | Cell proliferation; extracellular space; chemotaxis; interleukin-4 receptor binding; B-cell differentiation; T-helper 2 type immune response; cellular defense response; cholesterol metabolism; connective tissue growth factor biosynthesis; regulation of isotype switching | 9.63679381 | 1.16890173 | 0.81613764 | 3.7220775 | 2.20043825 | 1.565717883 |
| IL5 | Interleukin 5 (colony-stimulating factor, eosinophil) | Extracellular; immune response; inflammatory response; positive regulation of cell proliferation; cytokine activity; interleukin-5 receptor binding; hypersensitive response | 7.93629877 | 1.49643167 | 1.30074841 | 3.63138859 | 1.43450147 | 1.559777562 |
| IL6 | Interleukin 6 (interferon, beta 2) | Humoral immune response; negative regulation of cell proliferation; positive regulation of cell proliferation; cell surface receptor linked signal transduction; extracellular space; acute-phase response; cell-cell signaling; cytokine activity; interleukin-6 receptor binding | 3.4689024 | 1.01811895 | 3.96001262 | 1.05246174 | 2.00258984 | 4.185069361 |
| IL7 | Interleukin 7 | Extracellular; humoral immune response; positive regulation of cell proliferation; organogenesis; cell-cell signaling; interleukin-7 receptor binding | 2.27361139 | 1.96237312 | 2.19677239 | 1.5142724 | 1.44988391 | 1.418583441 |
| IL8 | Interleukin 8 | Immune response; intracellular signaling cascade; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; cell cycle arrest; extracellular space; soluble fraction; cell motility; cell-cell signaling; chemokine activity; chemotaxis; angiogenesis; regulation of cell adhesion; neutrophil chemotaxis; calcium-mediated signaling; interleukin-8 receptor binding; induction of positive chemotaxis; neutrophil activation; regulation of retroviral genome replication | 0.1335222 | 0.35942406 | 0.13590094 | 0.23689785 | 1.83093334 | 1.03244623 |
| IL9 | Interleukin 9 | Extracellular; immune response; inflammatory response; positive regulation of cell proliferation; cell-cell signaling; interleukin-9 receptor binding | 1.19731974 | 1.23996092 | 0.43462676 | 1.55514456 | 0.40694034 | 0.946526229 |
| INHA | Inhibin, alpha | Extracellular; protein binding; cell growth and/or maintenance; negative regulation of cell cycle; induction of apoptosis; cell surface receptor linked signal transduction; cell cycle arrest; growth factor activity; hormone activity; skeletal development; cell-cell signaling; cell differentiation; neurogenesis; cytokine activity; negative regulation of interferon-gamma biosynthesis; activin inhibitor activity; erythrocyte differentiation; hemoglobin biosynthesis; negative regulation of B-cell differentiation; negative regulation of follicle-stimulating hormone secretion; negative regulation of macrophage differentiation; negative regulation of phosphorylation; ovarian follicle development; positive | 1.32746285 | 1.2769295 | 0.88358932 | 1.04287598 | 0.67358137 | 0.730762637 |
| INHBA | Inhibin, beta A (activin A, activin AB alpha polypeptide) | Extracellular; protein binding; cell growth and/or maintenance; negative regulation of cell cycle; induction of apoptosis; mesoderm development; cell surface receptor linked signal transduction; cell cycle arrest; growth factor activity; hormone activity; skeletal development; cell-cell signaling; cell differentiation; Neurogenesis; defense response; cytokine activity; transforming growth factor beta receptor binding; negative regulation of interferon-gamma biosynthesis; growth; activin inhibitor activity; erythrocyte differentiation; hemoglobin biosynthesis; negative regulation of b-cell differentiation; negative regulation of follicle-stimulating hormone secretion; negative | 1.08073029 | 1.87227915 | 1.17236683 | 1.69650078 | 2.13238195 | 3.614676832 |
| INHBB | Inhibin, beta B (activin AB beta polypeptide) | Extracellular; protein binding; cell growth and/or maintenance; growth factor activity; hormone activity; cell-cell signaling; cell differentiation; defense response; cytokine activity; protein homodimerization activity; growth; negative regulation of follicle-stimulating hormone secretion; ovarian follicle development; positive regulation of follicle-stimulating hormone secretion; response to external stimulus; host cell surface receptor binding; negative regulation of hepatocyte growth factor biosynthesis | 3.59633698 | 1.68064664 | 1.09103593 | 1.25698631 | 2.60211969 | 0.677419361 |
| LTA | Lymphotoxin alpha (TNF superfamily, member 1) | Signal transduction; immune response; induction of apoptosis; membrane; cell-cell signaling; tumor necrosis factor receptor binding | 6.03872643 | 0.92303735 | 6.50682307 | 2.52759587 | 5.2510886 | 1.149333892 |
| LTB | Lymphotoxin beta (TNF superfamily, member 3) | Integral to membrane; signal transduction; immune response; cell-cell signaling; tumor necrosis factor receptor binding | 1.0086348 | 1.792797 | 6.96505111 | 1.09358159 | 5.41109041 | 0.882881616 |
| MDK | Midkine (neurite growth-promoting factor 2) | Cell proliferation; signal transduction; regulation of cell cycle; extracellular space; heparin binding; growth factor activity; cell-cell signaling; cell differentiation; neurogenesis; cytokine activity | 2.94380443 | 4.66579429 | 5.27988906 | 1.2295348 | 0.82412643 | 1.679094814 |
| NODAL | Nodal homolog (mouse) | Development; growth factor activity; cytokine activity | 4.9657434 | 1.81908917 | 1.40132893 | 1.7936727 | 0.72246576 | 1.594742743 |
| PDGFA | Platelet-derived growth factor alpha polypeptide | Cell proliferation; regulation of cell cycle; cell surface receptor linked signal transduction; membrane; extracellular space; growth factor activity; cell-cell signaling; platelet-derived growth factor receptor binding | 1.9297869 | 2.02531946 | 1.99717728 | 2.48247569 | 3.45445054 | 2.414740302 |
| PDGFB | Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | Cell proliferation; extracellular; cell growth and/or maintenance; regulation of cell cycle; membrane; response to wounding; growth factor activity; platelet-derived growth factor receptor binding | 0.83853903 | 0.97079553 | 0.95900676 | 0.85307547 | 1.31218767 | 0.441073007 |
| PTN | Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) | Cell proliferation; regulation of cell cycle; positive regulation of cell proliferation; extracellular space; heparin binding; growth factor activity; neurogenesis; cytokine activity; protein phosphatase inhibitor activity; transmembrane receptor protein tyrosine phosphatase signaling pathway | 1.5980138 | 1.24542208 | 0.87483804 | 0.91393046 | 1.16807059 | 0.985116858 |
| SPP1 | Secreted phosphoprotein 1 (osteopontin, bone sialoprotein, early T-lymphocyte activation 1) | Protein binding; anti-apoptosis; cell-matrix adhesion; extracellular matrix; growth factor activity; cell-cell signaling; cytokine activity; immune cell chemotaxis; integrin binding; positive regulation of T-cell proliferation; T-helper 1 type immune response; ossification; negative regulation of bone mineralization; regulation of myeloid blood cell differentiation; induction of positive chemotaxis; extracellular matrix (sensu Metazoa) | 1.87831749 | 3.00932904 | 5.74522182 | 0.62071966 | 12.4820223 | 1.80158236 |
| TGFA | Transforming growth factor, alpha | Cell proliferation; protein binding; protein-tyrosine kinase activity; regulation of cell cycle; signal transducer activity; integral to plasma membrane; extracellular space; soluble fraction; growth factor activity; cell-cell signaling; epidermal growth factor receptor activating ligand activity | 4.31496433 | 1.40547436 | 2.29988862 | 0.83922367 | 5.21695189 | 1.199012061 |
| TGFB1 | Transforming growth factor, beta 1 (Camurati-Engelmann disease) | Cell proliferation; anti-apoptosis; regulation of cell cycle; growth factor activity; cell-cell signaling; transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor binding; cell growth | 3.87456127 | 3.87868445 | 3.38612691 | 3.62205385 | 2.5987023 | 1.925692836 |
| TGFB2 | Transforming growth factor, beta 2 | 6.74713211 | 5.89042355 | 4.58762198 | 1.92222283 | 1.89256555 | 0.568599573 | |
| TGFB3 | Transforming growth factor, beta 3 | Cell proliferation; signal transduction; regulation of cell cycle; organogenesis; growth factor activity; cell-cell signaling; transforming growth factor beta receptor binding; cell growth | 5.09166362 | 6.78416947 | 4.71856209 | 4.15792631 | 3.33086612 | 1.843379256 |
| THPO | Thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) | Cell proliferation; extracellular; development; growth factor activity; hormone activity; cytokine activity; | 1.96988678 | 2.80676172 | 1.73069457 | 2.75051882 | 1.63698552 | 0.789714774 |
| TNF | Tumor necrosis factor (TNF superfamily, member 2) | Integral to membrane; signal transduction; immune response; regulation of transcription, DNA-dependent; apoptosis; anti-apoptosis; inflammatory response; response to virus; soluble fraction; cell-cell signaling; tumor necrosis factor receptor binding; leukocyte cell adhesion; necrosis | 1.40274268 | 1.33969398 | 2.29927615 | 2.06736798 | 4.45361783 | 0.795004677 |
| TNFRSF11 B | Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | Signal transduction; extracellular; protein binding; apoptosis; receptor activity; skeletal development; cytokine activity | 2.43667195 | 1.07216513 | 0.51648813 | 1.81762159 | 1.09420177 | 0.76648775 |
| TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 | Signal transduction; immune response; induction of apoptosis; apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; integral to plasma membrane; soluble fraction; cell-cell signaling; tumor necrosis factor receptor binding | 0.29859957 | 0.40336945 | 0.17101673 | 0.47425768 | 0.94754173 | 0.107686114 |
| TNFSF11 | Tumor necrosis factor (ligand) superfamily, member 11 | Extracellular; immune response; receptor activity; integral to plasma membrane; cell differentiation; tum or necrosis factor receptor binding; osteoclast differentiation | 1.84514703 | 1.58894407 | 0.76369915 | 1.55912449 | 1.15241823 | 0.537289446 |
| TNFSF12 | Tumor necrosis factor (ligand) superfamily, member 12 | Signal transduction; immune response; induction of apoptosis; apoptosis; integral to plasma membrane; angiogenesis; tumor necrosis factor receptor binding | 0.57298826 | 1.18267977 | 1.8772737 | 0.35582279 | 2.28919263 | 1.530630561 |
| TNFSF13 | Tumor necrosis factor (ligand) superfamily, member 13 | Signal transduction; immune response; positive regulation of cell proliferation; membrane; tumor necrosis factor receptor binding | 1.32075171 | 0.99920833 | 1.40025956 | 0.69674831 | 0.98571721 | 0.678497647 |
| TNFSF13B | Tumor necrosis factor (ligand) superfamily, member 13b | Cell proliferation; signal transduction; immune response; positive regulation of cell proliferation; integral to plasma membrane; soluble fraction; tumor necrosis factor receptor binding | 0.33414425 | 0.40715534 | 1.1565197 | 0.57007853 | 1.72446091 | 0.49062492 |
| TNFSF14 | Tumor necrosis factor (ligand) superfamily, member 14 | Integral to membrane; signal transduction; immune response; induction of apoptosis; tumor necrosis factor receptor binding; Caspase inhibitor activity; inhibition of Caspase activation; release of cytoplasmic sequestered NF-kappaB; T-cell proliferation; T-cell homeostasis | 1.56294653 | 1.72750559 | 0.74842096 | 2.28521965 | 1.01825948 | 0.973083683 |
| TNFSF15 | Tumor necrosis factor (ligand) superfamily, member 15 | Signal transduction; immune response; regulation of cell cycle; membrane; integral to plasma membrane; soluble fraction; tumor necrosis factor receptor binding | 1.66997676 | 1.44107317 | 0.90215988 | 1.84584106 | 0.93673721 | 1.080413403 |
| TNFSF18 | Tumor necrosis factor (ligand) superfamily, member 18 | Integral to membrane; signal transduction; immune response; anti-apoptosis; cell-cell signaling; tumor necrosis factor receptor binding | 1.82110465 | 1.26280989 | 0.56888294 | 1.59160549 | 0.76353241 | 0.610304864 |
| TNFSF4 | Tumor necrosis factor (ligand) superfamily, member 4 (tax-transcription ally activated glycoprotein 1, 34 kDa) | Signal transduction; immune response; positive regulation of cell proliferation; integral to plasma membrane; cell-cell signaling; tumor necrosis factor receptor binding | 0.85561258 | 0.69247961 | 0.36739997 | 0.43476557 | 0.49852032 | 0.189416647 |
| TNFSF5 | Tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome) | Signal transduction; immune response; anti-apoptosis; inflammatory response; integral to plasma membrane; soluble fraction; tumor necrosis factor receptor binding; CD40 receptor binding; B-cell proliferation; isotype switching; leukocyte cell adhesion; platelet activation | 0.56401054 | 1.26443741 | 1.05460831 | 0.86632133 | 1.70793484 | 0.636554156 |
| TNFSF6 | Tumor necrosis factor (ligand) superfamily, member 6 | Signal transduction; extracellular; immune response; induction of apoptosis; apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; integral to plasma membrane; cell-cell signaling; tumor necrosis factor receptor binding | 2.55725879 | 1.74148221 | 1.18322445 | 0.98551507 | 0.89388262 | 0.877481578 |
| TNFSF7 | Tumor necrosis factor (ligand) superfamily, member 7 | Cell proliferation; signal transduction; immune response; apoptosis; integral to plasma membrane; cell-cell signaling; tumor necrosis factor receptor binding | 1.79076183 | 1.86714014 | 1.11393837 | 0.96722807 | 0.66632963 | 1.07371487 |
| TNFSF8 | Tumor necrosis factor (ligand) superfamily, member 8 | Cell proliferation; signal transduction; immune response; induction of apoptosis; integral to plasma membrane; cell-cell signaling; tumor necrosis factor receptor binding | 16.6031255 | 16.1111832 | 4.28095125 | 11.2155931 | 4.62559223 | 5.704360903 |
| TNFSF9 | Tumor necrosis factor (ligand) superfamily, member 9 | Cell proliferation; signal transduction; immune response; apoptosis; integral to plasma membrane; cell-cell signaling; tumor necrosis factor receptor binding | 0.42683846 | 0.7782374 | 0.43051526 | 0.49961541 | 0.43147894 | 0.387778271 |
| VEGF | Vascular endothelial growth factor | Cell proliferation; signal transduction; extracellular; regulation of cell cycle; positive regulation of cell proliferation; homophilic cell adhesion; membrane; soluble fraction; heparin binding; growth factor activity; response to stress; vascular endothelial growth factor receptor binding; angiogenesis | 0.34493609 | 0.43924221 | 0.48077441 | 0.27217503 | 0.29507061 | 0.282455082 |
| PUC18 | PUC18 plasmid | – | N/A | N/A | N/A | N/A | N/A | N/A |
| VEGFB | Vascular endothelial growth factor B | Cell proliferation; regulation of cell growth; signal transduction; extracellular; regulation of cell cycle; positive regulation of cell proliferation; membrane; heparin binding; growth factor activity; vascular endothelial growth factor receptor binding | 0.59763504 | 0.75386562 | 1.02955742 | 0.6218807 | 0.85459142 | 0.466257659 |
| BLANK | – | – | N/A | N/A | N/A | N/A | N/A | N/A |
| AS1R2 | Artificial sequence 1 related 2 (80% identity) (48/60) | – | 1.5539686 | 1.22295593 | 1.32009457 | 0.98773529 | 0.52224864 | 0.591712439 |
| AS1R1 | Artificial sequence 1 related 1 (90% identity) (56/60) | – | 0.70736887 | 1.57696778 | 1.45720527 | 1.17608313 | 0.63025505 | 0.741073004 |
| AS1 | Artificial sequence 1 | – | 1.91282061 | 1.79068382 | 1.16574042 | 1.28525566 | 0.18929651 | 0.40325771 |
| GAPD | Glyceraldehyde-3-phosphate dehydrogenase | Cytoplasm; oxidoreductase activity; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity; glucose metabolism; glycolysis | 0.56074995 | 0.98897125 | 1.07548536 | 0.9254465 | 1.22393987 | 0.759341513 |
| B2M | Beta-2-microglobulin | Extracellular; immune response | 0.74661134 | 0.89668368 | 0.95250045 | 0.94572891 | 0.98168609 | 0.84607305 |
| HSPCB | Heat shock 90 kDa protein 1, beta | ATP binding; protein binding; cytoplasm; heat shock protein activity; protein folding; TPR domain binding; nitric-oxide synthase regulator activity; positive regulation of nitric oxide biosynthesis; unfolded protein binding; response to unfolded protein; ATP binding; protein binding; cytoplasm; heat shock protein activity; protein folding; TPR domain binding; nitric-oxide synthase regulator activity; positive regulation of nitric oxide biosynthesis; unfolded protein binding; response to unfolded protein | 0.72168097 | 0.90224818 | 1.1021151 | 0.77865346 | 1.05306214 | 0.792455408 |
| ACTB | Actin, beta | – | 0.99999138 | 0.99998711 | 0.99999156 | 1 | 1 | 0.999990471 |
| BAS2C | Biotinylated artificial sequence 2 complementary sequence | – | 1.16477022 | 1.05712391 | 1.10977505 | 1.04786113 | 0.40201837 | 0.545022077 |
| BAS2C | Biotinylated artificial sequence 2 complementary sequence | – | 0.92847709 | 1.0361002 | 1.04182707 | 1.01571793 | 0.62977964 | 0.72145099 |
INSIP, idiopathic nonspecific interstitial pneumonia; IPF, idiopathic pulmonary fibrosis; N/A, not applicable.