Fig. 2.

Effect of increasing doses of CER-001 and HDL3 on mean (±standard error of the mean) atherosclerotic plaque progression in ligatured carotid of apoE^−/− mice. The left carotid of apoE^−/− mice (n = 12) was ligatured, fed with a high-cholesterol diet and treated (retro-orbital injection) every second day with CER-001 or HDL3 (eight infusions). The carotids were lipid extracted and cholesterol levels were determined by high-performance liquid chromatography. a Unesterified cholesterol. b Total cholesterol. c Protein level of ABCA1 measured in the ligatured carotids using western blot analysis. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 vs. baseline. ABCA1 ATP-binding cassette transporter 1, apoE apolipoprotein E