Figure 1.

Behavioral tests including mechanical allodynia and depressive-like behaviors were performed. (A) Schematic timeline of the experimental procedure. The total distance (B) in the open field test was not significantly different among the four groups. (C) SNI elicited mechanical allodynia, while minocycline administration prevented SNI-induced decreases in mechanical withdrawal thresholds on days 7 and 14. (D) SNI increased the immobility time significantly in the forced swim test, while minocycline administration decreased the immobility time. (E) SNI reduced the sucrose consumption significantly and minocycline reversed this change. (F) No significant difference of the total liquid consumption was observed. The data are presented mean ± SEM (n = 12). ^*P < 0.05 compared to the Sham group, ^#P < 0.05 compared to the SNI group.