FIGURE 1.

Schematic design of the experimental protocol. Experiments were accomplished by administering pre-treatment (daily, beginning 1 h before immunization), onset-treatment (daily, beginning approximately 6–8 days following immunization), and post-treatment (daily, beginning 16–18 days following immunization) dosages of SHSST (300 or 600 mg/kg, p.o.). A behavioral test was evaluated at the same time of day, for 30 days following immunization. Spinal cords were sampled within 14–16 days after immunization.