FIGURE 8.

Effect of pre-treatment and post-treatment with SHSST on clinical symptoms of EAE mice. (A–D) SHSST (600 mg/kg) was orally administrated once daily from 1 h before immunization (pre-treatment; A and B) and peak stage (day 16–18 after immunization) of clinical sign (post-treatment; C and D) of EAE mice. After the immunization, clinical signs of all mice were scored (A,B); and the mice were weighed (C,D) daily until 30 days later. Data are expressed as mean clinical scores ±SEM. (ANOVA testing was performed; ^##p < 0.01 versus the sham group; ^∗∗p < 0.01 versus the EAE group.)