Table 2.
Overall and gender- and age-specific incidence densities and relative hazards of multiple sclerosis in the diabetes and comparison cohorts.
| Variables | Comparison cohort |
Diabetic cohort |
Crude HR (95% CI) in association with diabetic group | Adjusted HRb (95% CI)b in association with diabetic group | ||||
|---|---|---|---|---|---|---|---|---|
| n | Number of events | ID (per 10,000 patient-years) (95% CI)a | n | Number of events | ID (per 10,000 patient-years) (95% CI) | |||
| Men | ||||||||
| ≤50 years | 82,321 | 20 | 2.43 (1.48–3.75) | 81,204 | 35 | 4.31 (3.00–6.01) | 1.73 (1.00–3.05) | 1.66 (0.64–4.35) |
| >50 years | 212,884 | 24 | 1.13 (0.72–1.68) | 214,282 | 30 | 1.40 (0.95–2.00) | 1.26 (0.74–2.15) | 1.26 (0.69–2.26) |
| Total | 295,205 | 44 | 1.49 (1.08–2.03) | 295,486 | 65 | 2.20 (1.70–2.81) | 1.48 (1.01–2.17) | 1.34 (0.81–2.23) |
| Women | ||||||||
| ≤50 years | 64,479 | 30 | 4.65 (3.14–6.64) | 62,505 | 49 | 7.85 (5.8–10.37) | 1.65 (1.04–2.6) | 2.16 (1.02–4.59) |
| >50 years | 254,337 | 40 | 1.57 (1.12–2.14) | 256,632 | 61 | 2.38 (1.82–3.05) | 1.52 (1.02–2.26) | 1.24 (0.80–1.91) |
| Total | 318,816 | 70 | 2.21 (1.71–2.77) | 319,137 | 110 | 3.45 (2.83–4.16) | 1.57 (1.16–2.12) | 1.51 (1.05–2.19) |
| Overall | 614,021 | 114 | 1.86 (1.53–2.23) | 614,623 | 175 | 2.85 (2.44–3.30) | 1.53 (1.21–1.94) | 1.44 (1.08–1.94) |
CI, confidence interval; HR, hazard ratio; ID, incidence density.
p value for the interaction between diabetes and gender was 0.80.
p value for the interaction between diabetes and age was 0.39 and 0.79 for men and women, respectively.
Based on Poisson assumption.
Based on Cox proportional hazard regression, with adjustment for age; sex; income-based insurance premium; geographic area of living; urbanization status of living area; Charlson Comorbidity Index; frequency of medical visit; and selected co-morbidities, including allergy, Alzheimer's disease, anterior horn cell disease, COPD, obesity, vitamin D deficiency, dyslipidemia, hypertension, inflammatory bowel disease, spinal cord injury, stroke, thyroid disease, and traumatic brain injury, anxiety, depression, stress, tonsillectomy, and appendectomy.