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. 2017 Apr 10;8:15092. doi: 10.1038/ncomms15092

Figure 2. Architecture of the MERS-CoV and SARS-CoV S protomers.

Figure 2

(a) Schematic diagram of the MERS-CoV S glycoprotein organization. Black and grey dashed lines denote regions unresolved in the reconstruction and regions beyond the construct, respectively. NTD, N-terminal domain; L, linker region; RBD, receptor-binding domain; SD, subdomain; UH, upstream helix; FP, fusion peptide; CR, connecting region; HR, heptad repeat; CH, central helix; BH, β-hairpin; TM, transmembrane region/domain; CT, cytoplasmic tail. (b) Schematic diagram of the SARS-CoV S glycoprotein organization. The abbreviations of elements are the same as in a. (c–e) Ribbon diagrams depicting three views of the S protomer coloured as in a. As the MERS-CoV and SARS-CoV S protomers have extremely similar structures, and thus only MERS-CoV S protomer was used to show the detailed architecture.