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. 2017 Apr 14;37(9):e00584-16. doi: 10.1128/MCB.00584-16

FIG 4.

FIG 4

Expression of Gs-DREADD in liver elevates blood glucose levels. (A) Blood glucose levels in ad libitum-fed and fasted mice (means ± standard deviations; n = 10 per group). (B) Sik1 and Pgc-1α mRNA levels in mouse livers 5 to 8 weeks after AAV injection, normalized to Gapdh levels, expressed relative to values for AAV-TBG-GFP at 0 h. (C) Blood glucose levels after CNO injection (1 mg/kg s.c.) in ad libitum-fed mice (means ± standard errors of the means; n = 5 per group). (D) Liver glycogen levels in ad libitum-fed mice 0 h and 2 h after CNO injection (1 mg/kg s.c.) (means ± standard errors of the means; n = 3 to 5 mice per group). *, P < 0.05; **, P < 0.01; ***, P < 0.001; n.s., not significant (by t tests or ANOVA).