Table 3.
Effect of autophagy-related microRNAs (miRNAs) on radiotherapy.
| miRNAs | miRNA status in cancer | Effect on autophagy | Autophagy-related target | Effect on radiotherapy | Tested cell line (tissue origin) | Reference |
|---|---|---|---|---|---|---|
| miR-17 | Upregulated | Inhibition | ATG7 | Radioresistance | U373 (glioblastoma) | (83) |
| miR-21 | Upregulated | Inhibition | N.D. | Radioresistance | U373, U87 (glioblastoma) | (175) |
| miR-21 | Upregulated | Inhibition | PTEN | Radioresistance | HeLa, siHa (cervical) | (177) |
| miR-23b | Downregulated | Inhibition | ATG12 | Radiosensitivity | BxPC3 (pancreas) | (184) |
| miR-30b | Downregulated | Activation | BECN1 | N.D. | SH-SY5Y (neuroblastoma) | (190) |
| miR-32 | N.D. | Inhibition | DAB2IP | Radioresistance | PC3, DU145 (prostate) | (192) |
| miR-101 | Upregulated | Inhibition | STMN1 | Radiosensitivity | CNE-2, 5–8 F (nasopharyngeal carcinoma) | (199) |
| miR-199a-5p | N.D. | Inhibition | BECN1, DRAM1 | Radiosensitivity | MDA-MB-231 (breast) | (70) |
| miR-200c | N.D. | Activation | UBQLN1 | Radiosensitivity | MDA-MB-231 (breast) | (218) |
| miR-205 | N.D. | Inhibition | TP53INP1 | Radiosensitivity | DU145, LNCaP (prostate) | (221) |
| miR-216a | Upregulated | Inhibition | BECN1 | Radiosensitivity | PANC-1 (pancreas) | (80) |