Table 4. Subgroup analyses of tumor antigens on OS and DFS in CEA-high CRC patients.

	OS				DFS
	Univariate analysis	P	Multivariate analysis	P	Univariate analysis	P	Multivariate analysis	P
	HR (95% CI)		HR (95% CI)		HR (95% CI)		HR (95% CI)
Age (years)		0.235				0.452
≤60	1.000				1.000
>60	1.303 (0.841–2.019)				1.147 (0.803–1.639)
Gender		0.060				0.248
Male	1.000				1.000
Female	1.670 (0.978–2.851)				1.265 (0.849–1.887)
Tumor location		0.077				0.012		0.405
Colon	1.000				1.000		1.000
Rectum	0.676 (0.438–1.043)				0.636 (0.446–0.907)		0.807 (0.486–1.338)
Tumor length (cm)		0.503				0.747
≤3 cm	1.000				1.000
>3 cm	1.188 (0.718–1.965)				1.069 (0.714–1.599)
T stage		0.001		0.004		<0.001		0.063
T1	1.000		1.000		1.000		1.000
T2	0.670 (0.075–6.001)		1.063 (0.113–9.978)		1.360 (0.167–11.056)		1.371 (0.166–11.314)
T3	0.892 (0.122–6.534)		0.553 (0.072–4.263)		1.570 (0.217–11.365)		0.871 (0.117–6.479)
T4	2.066 (0.284–15.004)		1.320 (0.172–10.111)		3.598 (0.499–25.941)		1.727 (0.220–13.525)
N stage		<0.001		0.001		<0.001		0.002
N0	1.000		1.000		1.000		1.000
N1	2.954 (1.645–5.303)		2.497 (1.334–4.675)		1.765 (1.122–2.777)		1.360 (0.822–2.250)
N2	4.550 (2.573–8.048)		1.566(1.817–7.051)		3.150 (2.049–4.842)		2.566 (1.482–4.444)
Differentiation		0.118				0.008		0.878
Well/Moderate	1.000				1.000		1.000
Poor	1.625 (1.025–2.575)				1.797 (1.235–2.615)		1.095 (0.730–1.643)
Unknown	1.273 (0.395–4.101)				1.555 (0.569–4.250)		0.914 (0.321–2.599)
Venous invasion		<0.001		<0.001		<0.001		0.484
Negative	1.000		1.000		1.000		1.000
Positive	2.940 (1.906–4.534)		3.013 (2.090–4.344)		2.772 (1.943–3.953)		1.185 (0.736–1.907)
Perineural invasion		<0.001		<0.001		<0.001		0.038
Negative	1.000		1.000		1.000		1.000
Positive	2.285 (1.480–3.528)		2.019 (1.388–2.936)		2.142 (1.492–3.076)		1.530 (1.023–2.289)
CA199 (U/mL)		0.001		0.775		0.084
Normal (0–27)	1.000		1.000		1.000
High (>27)	2.102 (1.361–3.247)		1.094 (0.592–2.019)		1.367 (0.959–1.949)
CA50 (IU/mL)		<0.001		0.078		<0.001		0.118
Normal (0–25)	1.000		1.000		1.000		1.000
High (>25)	3.063 (1.919–4.887)		1.673 (0.944–2.963)		2.182 (1.441–3.303)		1.429 (0.913–2.236)
CA125 (U/mL)		0.292		0.122		<0.001		0.158
Normal (0–35)	1.000		1.000		1.000		1.000
High (>35)	3.085 (1.808–5.266)		1.639 (0.877–3.065)		2.367 (1.463–3.828)		1.466 (0.862–2.492)
CA242		0.003		0.538		0.095
Normal (0–25)	1.000		1.000		1.000
High (>35)	1.964 (1.268–3.042)		1.201 (0.671–2.149)		1.352 (0.949–1.925)
CA724 (U/mL)		<0.001		<0.001		<0.001		0.001
Normal (0–20)	1.000		1.000		1.000		1.000
High (>20)	3.096 (2.009–4.772)		2.853 (1.769–4.603)		2.166 (1.506–3.114)		2.059 (1.360–3.117)