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. 2017 Apr 18;7:46482. doi: 10.1038/srep46482

Figure 1. Cellular immune responses following immunization with viral-vectored vaccines (vv; ChAd63 or MVA) expressing different versions of PvCSP.

Figure 1

(A) Schematic representation of the CSP sequences expressed by ChAd63 and MVA vectors. NC: the amino (N)- and carboxyl-terminal (C)- sequences without central repeat regions (CR); N210C: a fragment containing the amino (N)- and carboxyl-terminal (C)- sequences flanking the VK210 allele; N247C: a fragment containing the amino (N)- and carboxyl-terminal (C)- sequences flanking the VK247 allele; N210/247CR:. a fragment containing the amino (N)- and carboxyl-terminal (C)- sequences flanking a chimeric fragment with both repeat sequences of the VK210 and VK247 central repeats, all contain an insertion region (IR); (B) Groups of mice of four strains (C57Bl6, C3H/HE, BALB/c, CD1, n = 6–8) were immunized with different vv using an Ad prime- and MVA boost regimen at an interval of 8 weeks and cellular responses were assessed by ex vivo IFN-γ ELISpot on week two after the MVA boost.