Figure 1. Loss of BabA expression in mice is not affected by B or T cell response.

H. pylori colonization was significantly greater in female RAG2−/− compared to WT mice at 2 and 8 weeks PI when the results were pooled over time, P < 0.0001 (a), but loss of the babA ORF was unaffected (b). Each point represents the percentage of colonies (average of 8 colonies total) from a single mouse determined by sequencing to express a full length babA ORF. Similar results were obtained when the experiment was repeated (c,d), although the difference in colonization level was less significant, P < 0.05 (c). Data were analyzed by two-way ANOVA of log (a,c) or logit (b,d) transformed values. *P < 0.05, **P < 0.01.