Table 4.
Postmatching Follow-Up: Differences in CV Event Rates and Mortality Among Statin Users in Statin Benefit Group 1
| Postindex CV events and mortalitya | High-intensity statin initiators (N = 23,340) | Low-/moderate-intensity statin initiators (N = 23,340) | P value |
|---|---|---|---|
| Follow-up length, days, mean (SD) | 865.2 (656.73) | 876.1 (657.47) | .073 |
| Follow-up length, days, median | 673 | 689 | |
| CV-related outcomes | |||
| Myocardial infarction | |||
| Patients with ≥1 events, N (%) | 2044 (8.8) | 1722 (7.4) | <.001 |
| Incidence rate per 1000 person-years | 39.9 | 32.7 | |
| Unstable angina in the inpatient/emergency department setting | |||
| Patients with ≥1 events, N (%) | 1992 (8.5) | 1816 (7.8) | .003 |
| Incidence rate per 1000 person-years | 39.0 | 34.8 | |
| Ischemic stroke | |||
| Patients with ≥1 events, N (%) | 870 (3.7) | 758 (3.2) | .005 |
| Incidence rate per 1000 person-years | 16.1 | 13.8 | |
| Transient ischemic attack | |||
| Patients with ≥1 events, N (%) | 655 (2.8) | 556 (2.4) | .004 |
| Incidence rate per 1000 person-years | 12.1 | 10.1 | |
| Coronary revascularization, including CABG and PCI | |||
| Patients with ≥1 events, N (%) | 1765 (7.6) | 1610 (6.9) | .006 |
| Incidence rate per 1000 person-years | 34.2 | 30.6 | |
| All-cause mortality,b N (%) | 621 (2.7) | 544 (2.3) | .022 |
| Incidence rate per 1000 person-years | 11.2 | 9.7 | |
| CV-related mortality using a claims-based algorithm,c N (%) | 83 (0.4) | 54 (0.2) | .013 |
| Incidence rate per 1000 person-years | 1.5 | 1.0 | |
| Composite CV outcome groupd | |||
| Patients with ≥1 events, N (%) | 4777 (20.5) | 4205 (18.0) | <.001 |
| Incidence rate per 1000 person-years | 103.1 | 87.0 | |
Postindex CV events and mortality were reported for the duration of available follow-up, unless otherwise specified. CV event was defined as inpatient or emergency department visits with claims containing any of the codes related to the CV event of interest based on an ICD-9-CM diagnosis/procedure codes or CPT codes. An emergency department visit and inpatient stay in succession (without any gap in dates of service) was considered the same event.
All-cause mortality was based on reported death in SSDI records or a hospital discharge status of “deceased” in claims.
Mortality was considered CV-related if the patient had ≥1 inpatient stays or emergency department visits with a CV event as the primary diagnosis within 30 days before or on the date of death.
Composite CV outcome group included ACS, stroke, coronary revascularization, and CV-related mortality.
ACS indicates acute coronary syndrome; CABG, coronary artery bypass grafting; CPT, Current Procedural Terminology; CV, cardiovascular; ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification; PCI, percutaneous coronary intervention; SD, standard deviation; SSDI, Social Security Death Index.