Table 3.

Brain regions showed altered FC in asthmatic patients compared with HCs.

Peak area	BA	Side	MNI coordinates			voxels Number	Peak t-value
			X	Y	Z
FC OF LEFT vAI
Cerebellum posterior lobe	−	L	−39	−69	−39	41	4.387
Middle temporal gyrus	21	R	66	−18	−24	50	4.6121
Anterior cingulate cortex	32	B	6	36	6	122	4.5451
Postcentral	6	R	54	−18	21	35	−4.4352
Postcentral	2	R	42	−33	42	71	−4.6205
Parietal Lobe	7	L	−18	−63	54	61	−4.6808
Parietal Lobe	7	R	30	−48	57	111	−4.5955
Precentral Gyrus	4	L	−18	−24	69	38	−4.7301
FC OF LEFT PI
Medial frontal gyrus	9	L	−12	42	33	38	4.5504
FC OF RIGHT vAI
Caudate	−	R	21	6	9	62	4.2601
Putamen	−	L	−24	3	3	40	4.1338
FC OF RIGHT dAI
Calcarine	30	L	−15	−72	9	64	−4.5115

Threshold was set at P < 0.005/6 (AlphaSim-corrected, cluster size > 945 mm³ for left vAI, left PI, right vAI, right dAI respectively). X, Y, Z, coordinates of primary peak locations in the MNI space.

MNI, Montreal Neurological Institute space; FC, functional connectivity; HCs, healthy controls; BA, Brodmann area; R, right; L, left; B, bilateral; vAI, ventral anterior insula; PI, posterior insula; dAI, dorsal anterior insula.