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(a) Generation of nociceptor specific knockout mice lacking PKG-I (SNS-PKG-I−/−) via Cre/loxP-mediated recombination by mating mice carrying the floxed prkg1 allele (PKG-Ifl/fl) with a mouse line expressing Cre recombinase under control of the Nav1.8 promoter (SNS-Cre). (b) Schematic diagram showing SNS-PKG-I−/− mice with a selective deletion of PKG-I in nociceptive DRG neurons in the ascending pain pathways, but without any change of PKG-I expression in the brain regions.
