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. 2017 Apr 5;13:1744806917701743. doi: 10.1177/1744806917701743

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — (a) Quantitative summary showing a dramatic reduction of pERK1/2 expression in both capsaicin and muscle pain models in mice lacking PKG-I in nociceptors, as compared to their PKG-I^fl/fl littermates. (b, c) Quantification of the number of Fos positive cells revealed that Fos immunoreactivity in both capsaicin and muscle pain models was greatly reduced in the superficial (b) and deep spinal dorsal horn (c) in SNS-PKG-I^−/− mice, as compared to PKG-I^fl/fl mice. *indicates statistically significant differences (P < 0.05) between PKG-I^fl/fl mice and SNS-PKG-I^−/− mice (ANOVA, post hoc Fisher’s test, n = 4 mice per genotype).