. 2017 Apr 18;7:46263. doi: 10.1038/srep46263

Table 1. Characteristics of the AD subtypes and healthy controls.

	Healthy controls (n = 230)	Alzheimer’s disease subtypes
	Healthy controls (n = 230)	Typical AD (n = 100, 50.5%)	Limbic-predominant (n = 33, 16.7%)	Hippocampal-sparing (n = 35, 17.7%)	No atrophy group (n = 30, 15.2%)	p-value
Age	75.9 (5.0)	77.7 (6.4)	72.3 (7.1)^a,b	78.2 (8.2)^c	69.2 (6.9)^a,b,d	<0.001
Gender, % female	48.7	37.0	57.6	48.6	73.3^b	0.016
Years of education	16.0 (2.9)	15.0 (3.4)^a	14.6 (2.2)	14.9 (3.1)	13.6 (3.7)^a	<0.001
MMSE	29.1 (1.0)	22.9 (2.1)^a	23.2 (1.9)^a	23.7 (2.2)^a	24.2 (1.5)^a,b	<0.001
CDR total	0 (0)	0.8 (0.2)^a	0.7 (0.2)^a,b	0.7 (0.3)^a	0.7 (0.2)^a,b	<0.001
Age at onset^e	—	73.6 (7.2)	68.6 (6.9)^b	76.3 (7.6)^c	66.8 (7.1)^b,d	<0.001
Disease duration^e	—	3.8 (2.6)	3.3 (2.2)	3.2 (2.7)	2.6 (1.4)	0.189
ApoE status, % ε4 allele	26.5	69.0^a	69.7^a	51.4^a	73.3^a	<0.001
CSF Aß_1-42, % abnormal^f	40.0	96.0^a	90.0^a	85.0^a	91.7^a	<0.001
CSF T-tau, % abnormal^g	21.2	56.0^a	75.0^a	75.0^a	66.7^a	<0.001

The table shows mean (SD) except for Gender, APOE status and the CSF biomarkers, where percentage is reported. ^aSignificantly different from Healthy controls; ^bSignificantly different from Typical AD; ^cSignificantly different from Limbic-predominant; ^dSignificantly different from Hippocampal-sparing. ^eN = 154; ^fN = 217; ^gN = 215. AD = Alzheimer’s disease; CDR = clinical dementia rating; MMSE = mini-mental state examination; APOE = apolipoprotein E; CSF = cerebrospinal fluid; Aß_1-42 = amyloid-ß-peptide 1–42; T-tau = total level of tau protein.