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. 2017 Jan 15;144(2):305–312. doi: 10.1242/dev.141135

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Proposed effects of CenpH depletion on meiotic resumption in mouse oocytes. Depletion of CenpH in mouse oocytes leads to elevated APC/C^Cdh1 activity and instability of cyclin B1. APC/C^Cdh1 is apparently the target of CenpH in mediating meiotic resumption. Increased expression of APC/C^Cdh1 perturbs cyclin B1 accumulation, resulting in prophase I arrest. Consequently, CenpH is crucial in balancing the G2/M transition in mouse oocytes.