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. 2017 Jan 1;130(1):292–302. doi: 10.1242/jcs.186320

Fig. 7.

Fig. 7.

Changes in elasticity of cell-populated matrices after drug treatments. (A) Temporal variations in shear-wave group velocities and gel volume compaction measured in CL1-5-populated collagen matrices. The samples were cultured without treatment [(−) BAPN; n=10] for 5 days or were treated daily with 350 µM aminopropionitrile [(+) BAPN; n=6]. After 5 days of culture, the samples in the normal culture group were either treated with 40 mM BDM for 9 h [5+BDM; n=4] or 30 µM blebbistatin [5+BLEB; n=5] to hinder cell contraction. (B) Temporal variations in shear-wave group velocities and gel volume compaction measured in collagen matrices cultured with H9C2 cells for 12 h (n=4) and those measured in H9C2-populated collagen matrices that were treated with 40 mM BDM for 9 h after culture of 12 h (n=3). To facilitate data comparison, the wave speeds and gel thickness measured at various time points in A and B were normalized to those measured immediately after the matrices gelation. Data shown in all figures is presented as mean±s.d.