Table 3.
Significant Results from Gene Set Enrichment Analysis of Cluster 14
| Database | Annotation | P Value | Corrected P Value |
|---|---|---|---|
| Reactome | SMAC-mediated apoptotic response | 0.000001 | 0.018322 |
| Reactome | Apoptosis | 0 | 0.005601 |
| BioCarta | Mitochondria pathway | 0 | 0.002736 |
| KEGG | Apoptosis | 0 | 0.001818 |
| Reactome | SMAC-mediated dissociation of IAP:caspase complexes | 0.000001 | 0.01649 |
| BioCarta | HIVNEF pathway | 0.000001 | 0.018034 |
| Reactome | SMAC binds to IAPs | 0.000001 | 0.01649 |
| BioCarta | Death pathway | 0 | 0.004703 |
| Reactome | Intrinsic pathway for apoptosis | 0 | 0.007846 |
| KEGG | Small cell lung cancer | 0.000002 | 0.032358 |
| GO | IL-1β secretion | 0.000003 | 0.0355 |
| Reactome | Programmed cell death | 0 | 0.004703 |
| Reactome | Apoptotic factor–mediated response | 0.000002 | 0.031471 |
Definition of abbreviations: GO = Gene Ontology; HIVNEF = HIV negative effector of Fas and TNF; IAP = inhibitor of apoptosis; KEGG = Kyoto Encyclopedia of Genes and Genomes; SMAC = second mitochondria-derived activator of caspase.
Enrichment was performed by Fisher exact test. P values were corrected for false discovery rate, using the Benjamini-Hochberg method.