Figure 10.

Somatic LTP recordings with resting GIRK conductance blocked by Ba²⁺. A, Schematic representing the experimental configuration. Voltage responses were measured at the soma. EPSPs were evoked using a stimulating electrode placed at the SC inputs (∼120–150 μm from soma). B, Example voltage traces recorded at the soma from dorsal (A) and ventral neurons (C) during five bursts of TBP train in the presence of BaCl₂. C, Time course plot of normalized EPSP slope (mean ± SEM) in dorsal neurons (n = 6) when TBP-LTP was induced in the presence of BaCl₂. Inset, Example EPSP traces recorded from dorsal somatic recordings during baseline and after TBP. D, Scatter plot comparing the amount of LTP in control recordings (blue, n = 10) versus LTP recordings in the presence of BaCl₂ (black, n = 6) in dorsal CA1 neurons (unpaired t test, t₍₁₄₎ = 1.7, p = 0.04). E, Time course plot of normalized EPSP slope (mean ± SEM) in ventral neurons (n = 6) when TBP-LTP was induced in the presence of BaCl₂. Inset, Example EPSP traces recorded from ventral neurons during baseline and after TBP. F, Scatter plot comparing the amount of LTP induced in control recordings (orange, n = 10) versus LTP recordings in the presence of BaCl₂ (red, n = 6) in ventral CA1 neurons (unpaired t test, t₍₁₄₎ = 0.6, p = 0.26). Open circles represent individual cells. Closed circles represent mean ± SEM.