Figure 6.

Proliferation of astrocytes derived from trkB.T1 KO mice was slower than that of WT mice, as identified by the xCelligence real-time cell analysis system. A, Baseline proliferation in serum-starved astrocytes was slower in trkB.T1 KO cells than in WT cells. N = 4 wells/group from two independent experiments. B, Astrocyte proliferation in response to 10% FBS was more rapid in WT cells than in trkB.T1 KO cells. N = 6 wells/group from three independent cultures. C, Proliferation in response to BDNF (50 ng/ml) was higher in WT astrocytes, than in KO astrocytes at as early as 12 h. N = 6 wells/group from three independent cultures. *p < 0.05, ***p < 0.001 versus WT (repeated measurements of two-way ANOVA with Student's Newman–Keuls post hoc analysis).