Table 3.
Change from baseline in metabolic variables in mild SCH patients combined with dyslipidemia.
| Variables | Sub-LT4 group (n = 116) | Subcontrol group (n = 91) | p value∗ | ||||
|---|---|---|---|---|---|---|---|
| Baseline | End-of-study | p value# | Baseline | End-of-study | p value# | ||
| BMI (kg/m2) | 26.48 ± 3.13 | 26.00 ± 3.27 | 0.001 | 26.17 ± 3.68 | 26.20 ± 3.88 | 0.865 | — |
| Weight (kg) | 66.92 ± 10.27 | 65.44 ± 9.97 | <0.001 | 66.12 ± 11.57 | 66.12 ± 12.03 | 0.993 | — |
| TC (mmol/L) | 6.27 ± 1.21 | 5.69 ± 1.15 | <0.001 | 5.99 ± 1.16 | 5.74 ± 1.14 | 0.026 | — |
| HDL-C (mmol/L) | 1.33 ± 0.36 | 1.31 ± 0.31 | 0.301 | 1.31 ± 0.34 | 1.42 ± 0.37 | <0.001 | — |
| LDL-C (mmol/L) | 3.67 ± 0.83 | 3.43 ± 0.91 | <0.001 | 3.55 ± 0.85 | 3.35 ± 0.94 | 0.015 | — |
| Non-HDL-C (mmol/L) | 4.93 ± 1.08 | 4.37 ± 1.03 | <0.001 | 4.68 ± 1.04 | 4.32 ± 1.02 | 0.001 | — |
| TG (mmol/L) | 1.82 (1.27) | 1.49 (1.04) | <0.001 | 1.84 (1.29) | 1.46 (0.90) | <0.001 | — |
| FPG (mmol/L) | 6.43 ± 1.54 | 6.35 ± 1.83 | 0.329 | 6.65 ± 2.04 | 6.50 ± 2.07 | 0.229 | — |
| Change in TC | −0.58 ± 0.92 | −0.25 ± 1.06 | 0.018 | ||||
| Change in LDL | −0.25 ± 0.63 | −0.20 ± 0.77 | 0.595 | ||||
| Change in Non-HDL-C | −0.56 ± 0.84 | −0.36 ± 0.95 | 0.102 | ||||
| Change in TG | −0.32 (0.88) | −0.34 (0.85) | 0.392 | ||||
Values are expressed as mean ± standard deviation or median (interquartile range).
∗ p value for comparing variables between sub-LT4 group and subcontrol group.
# p value for comparing variables between baseline and end-of-study within each group.
SCH: subclinical hypothyroidism; LT4: levothyroxine; BMI: body mass index; FPG: fasting plasma glucose; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; non-HDL-C: nonhigh-density lipoprotein cholesterol; TG: triglyceride.