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The CTS. The CTS is composed of a central pacemaker located in the SCN that displays autonomous circadian oscillations, but is also entrained by external cues such as light or socioprofessional activities. The SCN further generate rhythmic physiologic signals exerting a control on the autonomous molecular clocks present in each nucleated cell, which, in turn, induce oscillations in the expression of a large number of genes involved in key intracellular processes.
