Fig. 9.

Main outcomes of cancer patients according to circadian functioning status, estimated through assessment of rest-activity or salivary marker rhythms. Left panel: estimated 2-year survival rate (mean + 95% confidence limit) in a total of 1077 cancer patients (Cohen et al., 2012; Innominato et al., 2012; Lévi et al., 2014; Schrepf et al., 2015; Sephton et al., 2013; Sephton et al., 2000). Right panel: global quality of life domain (mean + standard error of the mean), derived from the EORTC QLQ-C30 questionnaire, completed by a total of 237 patients with mCRC (Innominato et al., 2009b).