TABLE 1.

Cell cycle components regulated by the mammalian circadian clock

Clock Regulators	Cell Cycle Targets	Mechanism	Cell Cycle Event	Reference
CLOCK:BMAL1	WEE1	Transcription	G2/M	Matsuo et al., 2003
REV-ERBα	P21	Transcription	G1	Grechez-Cassiau et al., 2008
NONO	P16/INK4	PPI	G1	Kowalska et al., 2013
DEC1	cMYC	Transcription	G1	Sun and Taneja, 2000
PER1	ATM, CHECK2	PPI	DNA damage	Gery et al., 2006
PER2	TP53	PPI	DNA damage	Gotoh et al., 2014
CRY2/TIMELESS	ATR, CHECK1	PPI	DNA damage	Unsal-Kaçmaz et al., 2005
CSNK1D	WEE1	Phos	G/2M	Penas et al., 2014
CSNK1E	CDC25	Phos	G2/M	Piao et al., 2011

Phos, phosphorylation; PPI, protein–protein interaction.