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5C1:2C2 in complex with FSK, ATP, Gαs, and GTPγS. View along the pseudo-twofold axis. 5C1, green; 2C2, cyan; Gαs helical domain, yellow; ras-like domain, mauve; atom colors: C, gray; N, blue; O, red; P, orange; Mg2+, violet. Models are based on the crystal structure PDB 1CJU (Tesmer et al., 1997, 1999) with ATP docked instead of 2′,3′-dideoxy-ATP. Secondary structure elements (Gαs only contact sites with 5C1:2C2) as well as N and C termini of 5C1:2C2 are labeled.
