TABLE 2.

Expression of mAC isoforms at the mRNA level

Expression pattern of AC isoforms in rodent brain and human tissue. Sanabra and Mengod (2011) used in situ hybridization to examine and compare the AC isoform expression in rodent brain tissues. Semiquantitative RT-PCR was used to examine and compare the AC isoform expressions in 16 human tissues (Ludwig and Seuwen, 2002).

AC Isoform	Rodent CNS Expression (Sanabra and Mengod, 2011)	Relative Human Tissue Abundance (Ludwig and Seuwen, 2002)
AC1	Hippocampus, cerebellum, cortex, and thalamus	Peripheral blood leukocytes > heart ∼ skeletal muscle ∼ kidney ∼ pancreas ∼ spleen ∼ testis ∼ ovary
AC2	Limbic and widespread	Skeletal muscle ∼ testis > heart ∼ prostate ∼ ovary ∼ colon
AC3	Widespread	Placenta ∼ testis ∼ ovary ∼ colon > lung ∼ spleen ∼ thymus
AC4	Not detected	Heart ∼ placenta ∼ lung ∼ spleen ∼ testis ∼ ovary ∼ small intestine
AC5	Caudate putamen and olfactory tubercle	Testis ∼ heart ∼ prostate ∼ ovary ∼ small intestine ∼ colon
AC6	Widespread	Heart ∼ kidney ∼ prostate ∼ testis ∼ ovary ∼ small intestine ∼ colon
AC7	Thalamus and hypothalamus	Peripheral blood leukocytes > placenta ∼ lung ∼ spleen ∼ thymus > heart ∼ liver ∼ ovary ∼ colon
AC8	Hippocampus, cerebellum, cortex, thalamus and hypothalamus	Testis (limited detection)
AC9	Cortex and hippocampus	Heart ∼ placenta ∼ lung ∼ liver ∼skeletal muscle ∼ kidney ∼ pancreas ∼ testis ∼ ovary ∼ peripheral blood leukocytes