TABLE 6.

Toxicity of BoNTs in mice upon i.p. injection expressed as LD₅₀ (ng/kg)

Toxin Type	LD50	Reference
BoNT/A1	1.15a	Duff, et al., 1957a
	0.45	Nakamura et al., 2010
	0.38	Pier et al., 2011
	0.40	Whitemarsh et al., 2013
	0.40	Pellett et al., 2015b
	0.25	Azarnia Tehran et al., 2015
BoNT/A2	0.11	Pier et al., 2011
	0.39	Whitemarsh et al., 2013
BoNT/A3	0.35	Whitemarsh et al., 2013
BoNT/A4	400–500	Whitemarsh et al., 2013
BoNT/A5	0.35	Whitemarsh et al., 2013
BoNT/B1	1.93a	Lamanna and Glassman, 1947
	1.23a	Duff, et al., 1957b
	0.41	Nakamura et al., 2010
	0.45b	Azarnia Tehran et al., 2015
BoNT/B2	0.40	Fan et al., 2016
BoNT/C1	5.00	Notermans et al., 1982
	2.30	Tsukamoto et al., 2005
	1.65	Morbiato et al., 2007
	0.92	Nakamura et al., 2010
BoNT/CD	1.42	Notermans et al., 1982
	1.80	Matsuda et al., 1986
	1.92	Tsukamoto et al., 2005
	0.80	Nakamura et al., 2010
BoNT/D	0.15	Tsukamoto et al., 2005
	0.18	Nakamura et al., 2010
	0.83	Eleopra et al., 2013
	0.43	Pellett et al., 2015b
	0.02b	Azarnia Tehran et al., 2015
BoNT/DC	0.05	Nakamura et al., 2010
BoNT/E1	0.65	Pier et al., 2011
	0.84	Chatla et al., 2012
	1.00	Meunier et al., 2003
BoNT/F1	2.50	Oishi and Sakaguchi, 1974
	10.0	Meunier et al., 2003
BoNT/FA	2.20	Fan et al., 2016
	1.30	Maslanka et al., 2016
BoNT/G	5.00	Schiavo et al., 1994

^aBoNT complexed as PTC.

^bToxins produced by recombinant methods.