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. 2015 May 27;5:10554. doi: 10.1038/srep10554

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This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Left set of pictures: gross morphologies of 12-week-old total CNP knockout mice with severe malocclusion (left) and normal occlusion (right) of the incisal teeth. Right: three-dimensional reconstructed image of a 12-week-old Nppc^−/− mouse with severe malocclusion. (b) Survival curves of total CNP knockout mice supplied with solid feed (▲) and pulverized feed (Δ). (c) Survival curves of Nppc^flox/flox (Δ) and Col2a1-Cre; Nppc^flox/flox (◊) mice.